Génétique de la narcolepsie humaine [Genetics of human narcolepsy]

Détails

ID Serval
serval:BIB_EF838284B903
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Génétique de la narcolepsie humaine [Genetics of human narcolepsy]
Périodique
Revue Neurologique
Auteur(s)
Dauvilliers Y., Tafti M., Billiard M.
ISSN
0035-3787[print], 0035-3787[linking]
Statut éditorial
Publié
Date de publication
2001
Volume
157
Numéro
11 Pt 2
Pages
S92-S96
Langue
français
Notes
Publication types: English Abstract ; Journal Article ; Review
Publication Status: ppublish
Résumé
Narcolepsy is known to be a complex disorder; both genetic and environmental factors play a role in its pathophysiology. Although narcolepsy presents one of the tightest association with a specific HLA antigen (DQB1*0602), there is strong evidence that non-HLA genes also confer susceptibility, both monoaminergic and hypocretinergic systems seem to be involved and may interfere with the phenotype. Implication of the hypocretin system is well-established in both canine and murine narcolepsy (caused by mutation) and a consistent reduction in hypocretin neuron seems to be the cause of human narcolepsy. An autoimmune process is probable.
Mots-clé
Animals, Dog Diseases/genetics, Dogs, Genetic Markers/genetics, Genetic Predisposition to Disease/genetics, Humans, Models, Genetic, Narcolepsy/genetics, Narcolepsy/veterinary, Phenotype, Twin Studies as Topic
Pubmed
Web of science
Création de la notice
24/01/2008 16:55
Dernière modification de la notice
03/03/2018 22:34
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