Alzheimer's patients engage an alternative network during a memory task.

Détails

ID Serval
serval:BIB_EF56165AFB5A
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Alzheimer's patients engage an alternative network during a memory task.
Périodique
Annals of Neurology
Auteur(s)
Pariente J., Cole S., Henson R., Clare L., Kennedy A., Rossor M., Cipoloti L., Puel M., Demonet J.F., Chollet F., Frackowiak R.S.
ISSN
0364-5134 (Print)
ISSN-L
0364-5134
Statut éditorial
Publié
Date de publication
2005
Volume
58
Numéro
6
Pages
870-879
Langue
anglais
Notes
Publication types: Journal Article Publication Status: ppublish. PDF type: Original Article
Résumé
We conducted an event-related functional magnetic resonance imaging experiment to better understand the potentially compensatory alternative brain networks activated by a clinically relevant face-name association task in Alzheimer's disease (AD) patients and matched control subjects. We recruited 17 healthy subjects and 12 AD patients at an early stage of the disease. They underwent functional magnetic resonance imaging scanning in four sessions. Each of the sessions combined a "study" phase and a "test" phase. Face/name pairs were presented in each study phase, and subjects were asked to associate faces with names. In the test phase, a recognition task, faces seen in the study phase were presented each with four different names. The task required selection of appropriate previously associated names from the study phase. Responses were recorded for post hoc classification into those successfully or unsuccessfully encoded. There were significant differences between the groups in accuracy and reaction time. Comparison of correctly versus incorrectly encoded and recognized pairs in the two groups indicated bilateral hippocampal hypoactivation both when encoding and recognizing in the AD group. Moreover, patients showed bilateral hyperactivation of parts of the parietal and frontal lobes. We discuss whether hyperactivation of a frontoparietal network reflects compensatory strategies for failing associative memory in AD patients.
Mots-clé
Aged, Alzheimer Disease/physiopathology, Association Learning/physiology, Female, Hippocampus/cytology, Hippocampus/physiology, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Neural Pathways/physiology, Parietal Lobe/cytology, Parietal Lobe/physiology, Pattern Recognition, Visual/physiology, Prefrontal Cortex/cytology, Prefrontal Cortex/physiology, Recognition (Psychology)/physiology
Pubmed
Web of science
Création de la notice
11/09/2011 19:14
Dernière modification de la notice
20/08/2019 17:17
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