Technique du ganglion sentinelle appliquée aux cancers de l'utérus: étude préliminaire [Sentinel lymph node biopsy in cervical and endometrial cancers: a feasibility study]

Details

Serval ID
serval:BIB_EECA15DDCDB3
Type
Article: article from journal or magazin.
Collection
Publications
Title
Technique du ganglion sentinelle appliquée aux cancers de l'utérus: étude préliminaire [Sentinel lymph node biopsy in cervical and endometrial cancers: a feasibility study]
Journal
Bulletin du cancer
Author(s)
Lelièvre L., Camatte S., Le Frère-Belda M.A., Kerrou K., Froissart M., Taurelle R., Vildé F., Lécuru F.
ISSN
0007-4551 (Print)
ISSN-L
0007-4551
Publication state
Published
Issued date
04/2004
Peer-reviewed
Oui
Volume
91
Number
4
Pages
379-384
Language
french
Notes
Publication types: Clinical Trial ; English Abstract ; Journal Article
Publication Status: ppublish
Abstract
The sentinel lymph node (SLN) biopsy has been proposed for the cancers of the uterus in order to optimize the diagnosis of lymphatic metastases and micrometastases in early stage tumors. Patients with early invasive cervical (n = 8) or endometrial (n = 15) cancers were enrolled. A lymphoscintigraphy was carried out before the intervention. Intraoperative SLN identification was performed with blue dye combined to a handheld gamma probe detection. Non-sentinel pelvic nodes were separately cleared out. SLNs were examined with frozen sections, permanent sections with hematoxylin-eosin staining and further serial sections with immunohistochemistry if negative. Six cervical cancer patients and 13 endometrial cancer patients had a positive lymphoscintigraphy, showing in 5 patients extra-iliac SLN(s). The intraoperative detection was successful in 6 cervical cancer patients and 14 endometrial cancer patients. The higher detection rate was obtained with the isotopic method. Most of the SLNs were ilio-obturator. Four endometrial cancer patients had a lymphatic spread, only involving the SLN in each case. No false negative SLN has been noted. SLN biopsy appears feasible in cervical and endometrial cancers. This procedure could improve the lymphatic evaluation of these cancers.
Keywords
Adult, Aged, Aged, 80 and over, Endometrial Neoplasms/pathology, False Negative Reactions, Feasibility Studies, Female, Humans, Immunohistochemistry, Lymphatic Metastasis/diagnosis, Middle Aged, Neoplasm Invasiveness, Sensitivity and Specificity, Sentinel Lymph Node Biopsy, Uterine Cervical Neoplasms/pathology
Pubmed
Web of science
Create date
03/03/2016 16:49
Last modification date
31/10/2019 13:07
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