Sensitivity of single-voxel 1H-MRS in investigating the metabolism of the activated human visual cortex at 7 T.

Details

Serval ID
serval:BIB_EB748C44F57E
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Sensitivity of single-voxel 1H-MRS in investigating the metabolism of the activated human visual cortex at 7 T.
Journal
Magnetic Resonance Imaging
Author(s)
Mangia S., Tkác I., Gruetter R., Van De Moortele P.F., Giove F., Maraviglia B., Uğurbil K.
ISSN
0730-725X (Print)
ISSN-L
0730-725X
Publication state
Published
Issued date
2006
Volume
24
Number
4
Pages
343-348
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't Publication Status: ppublish. PDF type: Research article
Abstract
Proton magnetic resonance spectroscopy (1H-MRS) has been used in a number of studies to noninvasively assess the temporal changes of lactate in the activated human brain. However, the results have not been consistent. The aim of the present study was to test the sensitivity of 1H-MRS during functional experiments at the highest magnetic field currently available for human studies (7 T). Stability and reproducibility of the measurements were evaluated from LCModel analysis of time series of spectra measured during a visual stimulation paradigm and by examination of the difference between spectra obtained at rest and during activation. The sensitivity threshold to detect concentration changes was 0.2 micromol/g for most of the quantified metabolites. The possible variations of metabolite concentrations during visual stimulation were within the same range (+/-0.2 micromol/g). In addition, the influence of a small line-narrowing effect due to the blood oxygenation level-dependent (BOLD) T2* changes on the estimated concentrations was simulated. Quantification of metabolites was, in general, not affected beyond 1% by line-width changes within 0.5 Hz.
Keywords
Humans, Magnetic Resonance Spectroscopy/methods, Magnetic Resonance Spectroscopy/statistics & numerical data, Protons, Sensitivity and Specificity, Visual Cortex/metabolism
Pubmed
Web of science
Create date
04/08/2010 15:28
Last modification date
20/08/2019 16:13
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