Role of lung fluid volume in growth and maturation of the fetal sheep lung

Details

Serval ID
serval:BIB_EAA19E3B41E2
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Role of lung fluid volume in growth and maturation of the fetal sheep lung
Journal
Journal of Clinical Investigation
Author(s)
Moessinger  A. C., Harding  R., Adamson  T. M., Singh  M., Kiu  G. T.
ISSN
0021-9738 (Print)
Publication state
Published
Issued date
10/1990
Volume
86
Number
4
Pages
1270-7
Notes
Journal Article --- Old month value: Oct
Abstract
We studied the effects of alterations in lung fluid volume on growth and maturation of the fetal lung. In a chronic fetal sheep preparation, right fetal lung volume was decreased by drainage of lung fluid while the volume of the left lung was expanded by mainstem bronchus ligation leading to lung fluid retention. After an experimental period of 25 d (from 105 to 129 d of gestation, term = 145 d), the right (deflated) lung was significantly hypoplastic and contained less DNA than the controls; 175.15 +/- 55.18 vs. 346.77 +/- 61.97 mg, respectively; P less than 0.001. In contrast, the left (expanded) lung was significantly hyperplastic and contained more DNA than the controls; 390.74 +/- 103.53 vs. 238.85 +/- 33.32 mg, respectively; P = 0.001. Biochemical indices of lung maturation, including total phospholipids, phosphatidylcholine, and disaturated phosphatidylcholine content expressed per unit of tissue DNA, were no different when comparing the hypoplastic, hyperplastic, and control lungs. These findings demonstrate that fetal lung cell multiplication is influenced by local distension with lung fluid, while the biochemical maturation of fetal lung surfactant is under systemic control.
Keywords
Animals DNA/analysis Extravascular Lung Water/*physiology Female Fetal Organ Maturity Lung/abnormalities/*embryology Lung Volume Measurements Organ Size Phosphatidylcholines/analysis Pregnancy Sheep
Pubmed
Web of science
Open Access
Yes
Create date
25/01/2008 13:16
Last modification date
20/08/2019 16:13
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