Article: article from journal or magazin.
Awakening dormant haematopoietic stem cells.
Nature Reviews. Immunology
Haematopoietic stem cells (HSCs) in mouse bone marrow are located in specialized niches as single cells. During homeostasis, signals from this environment keep some HSCs dormant, which preserves long-term self-renewal potential, while other HSCs actively self renew to maintain haematopoiesis. In response to haematopoietic stress, dormant HSCs become activated and rapidly replenish the haematopoietic system. Interestingly, three factors - granulocyte colony-stimulating factor, interferon-alpha and arsenic trioxide - have been shown to efficiently activate dormant stem cells and thereby could break their resistance to anti-proliferative chemotherapeutics. Thus, we propose that two-step strategies could target resistant leukaemic stem cells by priming tumours with activators of dormancy followed by chemotherapy or targeted therapies.
Animals, Arsenicals/immunology, Arsenicals/pharmacology, Bone Marrow/drug effects, Bone Marrow/immunology, Cell Growth Processes/drug effects, Cell Growth Processes/immunology, Granulocyte Colony-Stimulating Factor/immunology, Granulocyte Colony-Stimulating Factor/pharmacology, Hematopoietic Stem Cells/cytology, Hematopoietic Stem Cells/drug effects, Humans, Interferon-alpha/immunology, Interferon-alpha/pharmacology, Leukemia, Myelogenous, Chronic, BCR-ABL Positive/immunology, Lymphocyte Activation/drug effects, Mice, Oxides/immunology, Oxides/pharmacology, Stem Cell Niche/immunology
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