Awakening dormant haematopoietic stem cells.

Détails

ID Serval
serval:BIB_E9659304820C
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Editorial
Collection
Publications
Titre
Awakening dormant haematopoietic stem cells.
Périodique
Nature Reviews. Immunology
Auteur(s)
Trumpp A., Essers M., Wilson A.
ISSN
1474-1741 (Electronic)
ISSN-L
1474-1733
Statut éditorial
Publié
Date de publication
2010
Volume
10
Numéro
3
Pages
201-209
Langue
anglais
Résumé
Haematopoietic stem cells (HSCs) in mouse bone marrow are located in specialized niches as single cells. During homeostasis, signals from this environment keep some HSCs dormant, which preserves long-term self-renewal potential, while other HSCs actively self renew to maintain haematopoiesis. In response to haematopoietic stress, dormant HSCs become activated and rapidly replenish the haematopoietic system. Interestingly, three factors - granulocyte colony-stimulating factor, interferon-alpha and arsenic trioxide - have been shown to efficiently activate dormant stem cells and thereby could break their resistance to anti-proliferative chemotherapeutics. Thus, we propose that two-step strategies could target resistant leukaemic stem cells by priming tumours with activators of dormancy followed by chemotherapy or targeted therapies.
Mots-clé
Animals, Arsenicals/immunology, Arsenicals/pharmacology, Bone Marrow/drug effects, Bone Marrow/immunology, Cell Growth Processes/drug effects, Cell Growth Processes/immunology, Granulocyte Colony-Stimulating Factor/immunology, Granulocyte Colony-Stimulating Factor/pharmacology, Hematopoietic Stem Cells/cytology, Hematopoietic Stem Cells/drug effects, Humans, Interferon-alpha/immunology, Interferon-alpha/pharmacology, Leukemia, Myelogenous, Chronic, BCR-ABL Positive/immunology, Lymphocyte Activation/drug effects, Mice, Oxides/immunology, Oxides/pharmacology, Stem Cell Niche/immunology
Pubmed
Web of science
Création de la notice
03/02/2011 11:40
Dernière modification de la notice
20/08/2019 16:12
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