Awakening dormant haematopoietic stem cells.

Details

Serval ID
serval:BIB_E9659304820C
Type
Article: article from journal or magazin.
Publication sub-type
Editorial
Collection
Publications
Institution
Title
Awakening dormant haematopoietic stem cells.
Journal
Nature Reviews. Immunology
Author(s)
Trumpp A., Essers M., Wilson A.
ISSN
1474-1741 (Electronic)
ISSN-L
1474-1733
Publication state
Published
Issued date
2010
Volume
10
Number
3
Pages
201-209
Language
english
Abstract
Haematopoietic stem cells (HSCs) in mouse bone marrow are located in specialized niches as single cells. During homeostasis, signals from this environment keep some HSCs dormant, which preserves long-term self-renewal potential, while other HSCs actively self renew to maintain haematopoiesis. In response to haematopoietic stress, dormant HSCs become activated and rapidly replenish the haematopoietic system. Interestingly, three factors - granulocyte colony-stimulating factor, interferon-alpha and arsenic trioxide - have been shown to efficiently activate dormant stem cells and thereby could break their resistance to anti-proliferative chemotherapeutics. Thus, we propose that two-step strategies could target resistant leukaemic stem cells by priming tumours with activators of dormancy followed by chemotherapy or targeted therapies.
Keywords
Animals, Arsenicals/immunology, Arsenicals/pharmacology, Bone Marrow/drug effects, Bone Marrow/immunology, Cell Growth Processes/drug effects, Cell Growth Processes/immunology, Granulocyte Colony-Stimulating Factor/immunology, Granulocyte Colony-Stimulating Factor/pharmacology, Hematopoietic Stem Cells/cytology, Hematopoietic Stem Cells/drug effects, Humans, Interferon-alpha/immunology, Interferon-alpha/pharmacology, Leukemia, Myelogenous, Chronic, BCR-ABL Positive/immunology, Lymphocyte Activation/drug effects, Mice, Oxides/immunology, Oxides/pharmacology, Stem Cell Niche/immunology
Pubmed
Web of science
Create date
03/02/2011 11:40
Last modification date
20/08/2019 16:12
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