The neuropeptide Y Y1 receptor mediates NPY-induced inhibition of the gonadotrope axis under poor metabolic conditions

Details

Serval ID
serval:BIB_E8E336A9D692
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
The neuropeptide Y Y1 receptor mediates NPY-induced inhibition of the gonadotrope axis under poor metabolic conditions
Journal
FASEB Journal
Author(s)
Gonzales  C., Voirol  M. J., Giacomini  M., Gaillard  R. C., Pedrazzini  T., Pralong  F. P.
ISSN
1530-6860 (Electronic)
Publication state
Published
Issued date
01/2004
Volume
18
Number
1
Pages
137-9
Notes
Journal Article --- Old month value: Jan
Abstract
Hypothalamic neuropeptide Y (NPY) plays a central role in the control of food intake, energy balance, and modulation of neuroendocrine functions. In particular, an increase in NPY expression participates in the inhibition of the reproductive activity under poor nutritional conditions. The present study was designed to evaluate further the involvement of the Y1 subtype of NPY receptors in these effects. Food intake, body weight gain, and the onset of puberty were studied in groups of wild-type and Y1 deficient mice that were either fed ad libitum or subjected to a 30% restriction in food intake. This moderate feeding restriction induced a similar deficit in body weight gain in wild-type and in Y1 knockout mice. However, although wild-type mice experienced the expected delay of puberty, all mice in the food restriction group and lacking Y1 could go through puberty over the time of the experiment despite decreases in circulating leptin levels and increases in hypothalamic NPY expression. This observation demonstrates that the absence of Y1 impairs the perception of decreasing energy stores by the gonadotrope axis, demonstrating a physiological role for Y1 in the sensing of endogenous metabolic parameters by the hypothalamus.
Keywords
Adaptation, Physiological Animals Caloric Restriction Eating Female Gonadotropins/analysis Hypothalamus/*physiology Mice Mice, Knockout Neuropeptide Y/genetics/*physiology Neurosecretory Systems/physiology Receptors, Neuropeptide Y/*physiology Sexual Maturation/*physiology Weight Gain
Pubmed
Web of science
Create date
25/01/2008 8:45
Last modification date
20/08/2019 16:11
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