Hepatic arterial chemoembolization in the management of advanced digestive endocrine tumours.

Details

Serval ID
serval:BIB_E8975D53AC07
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Hepatic arterial chemoembolization in the management of advanced digestive endocrine tumours.
Journal
Italian Journal of Gastroenterology and Hepatology
Author(s)
Dominguez S., Denys A., Menu Y., Ruszniewski P.
ISSN
1125-8055[print], 1125-8055[linking]
Publication state
Published
Issued date
1999
Volume
31
Number
Suppl. 2
Pages
S213-S215
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
Liver metastases, in patients with gastroenteropancreatic endocrine tumours, are present in 25-90%, depending on the nature of the primary tumour. Surgical resection is indicated only for localised liver metastasis, whereas in most cases with diffuse liver involvement other therapeutic modalities such as intravenous chemotherapy, embolization or hepatic arterial chemoembolization, ligation or intra-arterial chemotherapy are currently available. Hepatic arterial chemoembolization is specifically indicated for progressive tumours (mainly carcinoids) confined to the liver especially after unsuccessful systemic chemotherapy. A mixture of cytotoxic drug and iodised oil followed by gelatine sponge particles are injected in the branches of the hepatic artery supplying the tumours. 66-100% positive results of this treatment have been reported in the carcinoid syndrome with a 50-91% decrease in 5-HIAA secretion. Variation of tumour size (WHO criteria) has been reported in 33-80% of the cases, even if no direct comparison between chemoembolization and other therapeutic modalities are currently available. Extensive follow-up of the treated patients and additional studies will clarify the role of chemoembolisation in advanced digestive neuroendocrine tumours.
Keywords
Antineoplastic Combined Chemotherapy Protocols/administration & dosage, Carcinoid Tumor/mortality, Carcinoid Tumor/secondary, Chemoembolization, Therapeutic, Clinical Trials as Topic, Digestive System Neoplasms/mortality, Digestive System Neoplasms/pathology, Female, Hepatic Artery, Humans, Infusions, Intra-Arterial, Liver Neoplasms/mortality, Liver Neoplasms/secondary, Male, Prognosis, Severity of Illness Index, Survival Rate, Treatment Outcome
Pubmed
Web of science
Create date
17/03/2010 10:30
Last modification date
20/08/2019 17:11
Usage data