Article: article from journal or magazin.
Case report (case report): feedback on an observation with a short commentary.
Neuropathie subaiguë, cancers multiples et syndrome de Gougerot-Sjögren: intérêt des anticorps anti-Hu [Subacute neuropathy, multiple cancers, and Gougerot-Sjögren syndrome: contribution of anti-Hu antibody].
Publication types: Case Reports ; English Abstract ; Journal Article
We report the case of a patient presenting a subacute, predominantly sensory neuropathy. The work up revealed a Sjögren's syndrome and a breast carcinoma. The presence of anti-Hu antibodies, identified by Western Blot using purified recombinant HuD protein, and the absence of the Hu antigen in the breast carcinoma ruled out the responsibility of the Sjögren's syndrome or breast carcinoma. In this context, the most likely diagnosis was a subacute neuropathy associated with small cell lung cancer, which was indeed discovered 3 years later.
Aged, Autoantibodies/analysis, Breast Neoplasms/immunology, Breast Neoplasms/pathology, Carcinoma, Small Cell/pathology, Female, Hu Paraneoplastic Encephalomyelitis Antigens, Humans, Lung Neoplasms/immunology, Lung Neoplasms/pathology, Neoplasms, Multiple Primary/complications, Neoplasms, Multiple Primary/diagnosis, Nerve Tissue Proteins/analysis, Nerve Tissue Proteins/immunology, Nervous System Diseases/complications, Nervous System Diseases/diagnosis, RNA-Binding Proteins/analysis, RNA-Binding Proteins/immunology, Sjogren's Syndrome/complications, Sjogren's Syndrome/diagnosis
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