Language representation in a patient with a dominant right hemisphere: fMRI evidence for an intrahemispheric reorganisation.

Details

Serval ID
serval:BIB_E5E6CB3DA9D7
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Language representation in a patient with a dominant right hemisphere: fMRI evidence for an intrahemispheric reorganisation.
Journal
Neuroreport
Author(s)
Seghier M., Lazeyras F., Momjian S., Annoni J.M., de Tribolet N., Khateb A.
ISSN
0959-4965
Publication state
Published
Issued date
2001
Peer-reviewed
Oui
Volume
12
Number
13
Pages
2785-2790
Language
english
Notes
Case Reports Journal Article Research Support, Non-U.S. Gov't --- Old month value: Sep 17
Abstract
Studies have suggested that congenital left hemispheric (LH) frontal arteriovenous malformations (AVMs) are associated with an early transfer of language to right hemisphere (RH) frontal regions. The question remains whether such anatomofunctional reorganisation is due to RH compensatory abilities or to a general principle of lateral shift. In this study, we used fMRI language paradigms to investigate the case of a patient presenting aphasic symptoms following an haemorrhage due to a right frontal AVM. Prior to surgery, fMRI showed that language processing was confined to the RH, suggesting that language had not shifted during childhood from this congenitally dominant RH to the LH. After surgery, the patient presented severe aphasia that recovered to presurgical level within 70 days. At this time, fMRI showed that language tasks were still not associated with activations in the LH. These results suggest that the principles of early cerebral reorganisation after congenital lesions may differ in the RH and the LH. In addition, they support the idea that efficient restoration of language is achieved if a sufficiently large neuronal network is preserved around the lesion.
Keywords
Adult, Aphasia, Brain Mapping, Cerebral Cortex, Dominance, Cerebral, Humans, Intracranial Arteriovenous Malformations, Language, Language Tests, Magnetic Resonance Imaging, Male, Nerve Net, Neuronal Plasticity, Recovery of Function, Verbal Behavior
Pubmed
Web of science
Create date
25/01/2008 11:37
Last modification date
20/08/2019 16:09
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