Biological effects of a dietary omega-3 polyunsaturated fatty acids supplementation in cystic fibrosis patients: a randomized, crossover placebo-controlled trial.

Details

Serval ID
serval:BIB_E4584C2980DA
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Biological effects of a dietary omega-3 polyunsaturated fatty acids supplementation in cystic fibrosis patients: a randomized, crossover placebo-controlled trial.
Journal
Clinical Nutrition
Author(s)
Panchaud A., Sauty A., Kernen Y., Decosterd L.A., Buclin T., Boulat O., Hug C., Pilet M., Roulet M.
ISSN
0261-5614 (Print)
ISSN-L
0261-5614
Publication state
Published
Issued date
06/2006
Peer-reviewed
Oui
Volume
25
Number
3
Pages
418-427
Language
english
Notes
Publication types: Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
BACKGROUND AND AIMS: Various anti-inflammatory therapies, including dietary omega-3 polyunsaturated fatty acids (PUFA) supplementation, have been investigated in cystic fibrosis (CF) patients. To further explore this nutritional approach, biological effects of an omega-3 PUFA oral liquid supplementation were measured in 17 CF patients in a double-blind, randomized, crossover without a washout period and placebo-controlled study.
METHODS: CF patients (age: 18+/-9 year; weight: 43+/-13 kg) received a liquid dietary supplementation either enriched or not in omega-3 PUFA (390-1170 mg/day according to patient weight) during two 6-month periods.
RESULTS: Increase in eicosapentaenoic acid was observed in neutrophil membrane following omega-3 PUFA dietary supplementation (from 0.7+/-0.6 to 1.6+/-0.6 micromol%, P<0.01). The leukotriene B(4) (LTB(4))/leukotriene B(5) (LTB(5)) ratio was decreased (from 72+/-27 to 24+/-7, P<0.001) in CF patients taking omega-3 PUFA supplements. In contrast, omega-3 PUFA supplementation affected neither internalization of IL-8 receptors following IL-8 exposure, nor IL-8-induced neutrophil chemotaxis.
CONCLUSION: Our results show that omega-3 PUFA are incorporated in neutrophil membranes. The subsequent decrease in LTB(4)/LTB(5) ratio suggests that, in such conditions, neutrophils may produce less pro-inflammatory mediators from the acid arachidonic pathway. These data indicate that omega-3 PUFA intake may have anti-inflammatory effect that still need to be assessed by long-term studies following large groups of patients.
Keywords
Adolescent, Adult, Cell Membrane/chemistry, Chemotaxis, Leukocyte/drug effects, Child, Cross-Over Studies, Cystic Fibrosis/therapy, Dietary Supplements, Eicosapentaenoic Acid/analogs & derivatives, Eicosapentaenoic Acid/blood, Fatty Acids, Omega-3/administration & dosage, Humans, Interleukin-8/pharmacology, Leukotriene B4/analogs & derivatives, Leukotriene B4/blood, Neutrophils/ultrastructure, Placebos, Receptors, Interleukin/drug effects, Receptors, Interleukin/metabolism
Pubmed
Web of science
Create date
25/01/2008 11:51
Last modification date
20/08/2019 17:07
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