Assisted circulation without systemic heparinization

Details

Serval ID
serval:BIB_E2395E926054
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Assisted circulation without systemic heparinization
Journal
Journal of Cardiothoracic and Vascular Anesthesia
Author(s)
Weiss  B. M., von Segesser  L. K., Turina  M. I., Vetter  W., Seifert  B., Pasch  T.
ISSN
1053-0770
Publication state
Published
Issued date
04/1994
Peer-reviewed
Oui
Volume
8
Number
2
Pages
168-74
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Apr
Abstract
The need for improvements in materials and equipment for extracorporeal circulation has been obvious for years. Among the surfaces with biologically active compounds, those with heparin binding have been found sufficiently thromboresistant and particularly suitable for different types of artificial perfusion. Partial left heart bypass (LHBP) was performed in 10 anesthetized, acutely instrumented, and open-chested mongrel dogs (weight 23 to 50 kg) with a servo-controlled roller pump. The pump flow was maintained at 50 mL/kg/min for 6 hours. Heparin surface-coated equipment was used without additional heparin. For LHBP with a standard circuit, the total amount of heparin during the study period was (mean +/- SD) 487 +/- 124 IU/kg. The right atrial, pulmonary artery, and left ventricular end-diastolic pressures, cardiac output, left ventricular output, right and left ventricular stroke work, pulmonary gas exchange, and acid-base balance changed similarly with both systems. Blood loss (204 +/- 78 v 1,240 +/- 586 mL, P < 0.0005), volume substitution requirements (647 +/- 48 v 1,860 +/- 764 mL, P < 0.0025), and oxygen extraction ratio (mean 25.4 to 32.0 v 25.4 to 56.4%, P < 0.025) were significantly lower, and mean aortic pressure (mean 65 to 69 v 62 to 38 mmHg, P < 0.025) and hemoglobin concentration (mean 9.1 to 8.1 v 9.4 to 3.9 g/dL, P < 0.05) were significantly higher during 6 hours of LHBP without systemic heparinization. Low but stable oxygen delivery was provided with heparin-coated LHBP, whereas it showed a descending trend (mean 14.0 to 10.8 v 13.4 to 5.5 mL/kg/min, P < 0.1) with the standard circuit.(ABSTRACT TRUNCATED AT 250 WORDS)
Keywords
Animals Atrial Function, Right/physiology Biocompatible Materials/*chemistry Blood Loss, Surgical Blood Pressure/physiology Blood Transfusion Cardiac Output/physiology Dogs Extracorporeal Circulation/*instrumentation Heart Rate/physiology *Heart-Assist Devices Hemoglobins/analysis Heparin/blood/*chemistry/therapeutic use Oxygen/blood Prospective Studies Pulmonary Artery/physiology Stroke Volume/physiology Surface Properties Ventricular Function, Left/physiology Ventricular Function, Right/physiology Ventricular Pressure/physiology Whole Blood Coagulation Time
Pubmed
Create date
14/02/2008 14:15
Last modification date
20/08/2019 16:06
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