Expression of CD31 by cells of extensive ductal in situ and invasive carcinomas of the breast.

Details

Serval ID
serval:BIB_E1CC3154B5F3
Type
Article: article from journal or magazin.
Collection
Publications
Title
Expression of CD31 by cells of extensive ductal in situ and invasive carcinomas of the breast.
Journal
Journal of Pathology
Author(s)
Sapino A., Bongiovanni M., Cassoni P., Righi L., Arisio R., Deaglio S., Malavasi F.
ISSN
0022-3417 (Print)
ISSN-L
0022-3417
Publication state
Published
Issued date
2001
Peer-reviewed
Oui
Volume
194
Number
2
Pages
254-261
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't Publication Status: ppublish
Abstract
CD31, an adhesion molecule expressed by endothelial cells, leukocytes, and platelets, is used in surgical pathology as a marker of normal and neoplastic vascularization. During the assessment of angiogenesis in breast carcinomas, CD31 expression was observed in a single case of large (5.2 cm diameter) high nuclear grade ductal carcinoma in situ (HG-DCIS) associated with poorly differentiated invasive ductal carcinoma (G3-IDC). Expression was limited to the cell membrane. This study focused on 32 HG-DCIS> or = 2 cm, either pure or associated with IDC. Cancer cells wereCD31(+) in 11 cases. Double staining using anti-CD31 monoclonal antibody (MAb) and anti-CD44 MAb, the anti-hyaluronate receptor, showed that foci of CD31(+) and CD44(-) tumour cells could be traced throughout the glandular tree, marking the intraductal diffusion of tumour up to Paget's cells at the nipple. The associated G3-IDC and their lymph node metastases were instead CD31(+) and CD44(+). CD31(+) tumours were oestrogen receptor (ER)(-), frequently p53(+) and c-erb-B2(+), and infiltrated by CD4(+) T lymphocytes. Normal and hyperplastic epithelia were constantly CD31(-). Other endothelial markers (e.g Factor VIII-RA and CD34) were not expressed by carcinoma cells, as was CD38, the CD31 ligand. In conclusion, CD31 expression is a feature acquired by breast cancer cells in the DCIS model. CD31 expression mainly correlates with tumour cells spreading within the ductal system. Finally, the invasive phenotype requires the co-expression of CD31 and CD44.
Keywords
Aged, Aged, 80 and over, Antigens, CD31/analysis, Antigens, CD44/analysis, Anus Neoplasms/immunology, Breast Neoplasms/blood supply, Breast Neoplasms/immunology, Carcinoma in Situ/blood supply, Carcinoma in Situ/immunology, Carcinoma, Ductal, Breast/blood supply, Carcinoma, Ductal, Breast/immunology, Case-Control Studies, Female, Humans, Middle Aged, Neovascularization, Pathologic, Paget Disease, Extramammary/immunology, Paget's Disease, Mammary/immunology, Tumor Markers, Biological/analysis, Vulvar Neoplasms/immunology
Pubmed
Web of science
Create date
05/02/2015 15:08
Last modification date
20/08/2019 16:05
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