Pediatric drug-related problems: a multicenter study in four French-speaking countries.

Details

Serval ID
serval:BIB_E1BFD33338C3
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Pediatric drug-related problems: a multicenter study in four French-speaking countries.
Journal
International Journal of Clinical Pharmacy
Author(s)
Prot-Labarthe S., Di Paolo E.R., Lavoie A., Quennery S., Bussières J.F., Brion F., Bourdon O.
ISSN
2210-7711 (Electronic)
Publication state
Published
Issued date
2013
Volume
35
Number
2
Pages
251-259
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish. PDF type: Research article
Abstract
BACKGROUND: Pediatric intensive care patients represent a population at high risk for drug-related problems. There are few studies that compare the activity of clinical pharmacists between countries.
OBJECTIVE: To describe the drug-related problems identified and interventions by four pharmacists in a pediatric cardiac and intensive care unit.
SETTING: Four pediatric centers in France, Quebec, Switzerland and Belgium.
METHOD: This was a six-month multicenter, descriptive and prospective study conducted from August 1, 2009 to January 31, 2010. Drug-related problems and clinical interventions were compiled from four pediatric centers in France, Quebec, Switzerland and Belgium. Data on patients, drugs, intervention, documentation, approval and estimated impact were compiled.
MAIN OUTCOME MEASURE: Number and type of drug-related problems encountered in a large pediatric inpatient population.
RESULTS: A total of 996 interventions were recorded: 238 (24 %) in France, 278 (28 %) in Quebec, 351 (35 %) in Switzerland and 129 (13 %) in Belgium. These interventions targeted 270 patients (median 21 months old, 53 % male): 88 (33 %) in France, 56 (21 %) in Quebec, 57 (21 %) in Switzerland and 69 (26 %) in Belgium. The main drug-related problems were inappropriate administration technique (29 %), untreated indication (25 %) and supra-therapeutic dose (11 %). The pharmacists' interventions were mostly optimizing the mode of administration (22 %), dose adjustment (20 %) and therapeutic monitoring (16 %). The two major drug classes that led to interventions were anti-infectives for systemic use (23 %) and digestive system and metabolism drugs (22 %). Interventions mainly involved residents and all clinical staff (21 %). Among the 878 (88 %) proposed interventions requiring physician approval, 860 (98 %) were accepted.
CONCLUSION: This descriptive study illustrates drug-related problems and the ability of clinical pharmacists to identify and resolve them in pediatric intensive care units in four French-speaking countries.
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Web of science
Create date
20/06/2013 17:03
Last modification date
20/08/2019 16:05
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