Reirradiation in squamous cell head and neck cancer: recent developments and future directions.

Details

Serval ID
serval:BIB_E1985ABB270C
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Reirradiation in squamous cell head and neck cancer: recent developments and future directions.
Journal
Current Opinion in Oncology
Author(s)
Langendijk J.A., Bourhis J.
ISSN
1040-8746 (Print)
ISSN-L
1040-8746
Publication state
Published
Issued date
2007
Peer-reviewed
Oui
Volume
19
Number
3
Pages
202-209
Language
english
Notes
Publication types: Journal Article ; Review Publication Status: ppublish
Abstract
PURPOSE OF REVIEW: The purpose of this review is to highlight the most important developments in the management of recurrent or second primary head and neck carcinoma in previously irradiated areas by reirradiation that have been published in the medical literature in the past year.
RECENT FINDINGS: Recent research indicates that long-term survival can be achieved in a proportion of patients using more advanced chemo-reirradiation protocols in the primary as well as in postoperative reirradiation setting. Despite the promising results with regard to locoregional tumour control and survival, treatment-related acute and late morbidity remains of major concern.
SUMMARY: As an increasing number of patients currently receive more effective initial treatment regimens, recurrent and second primary tumours in previously irradiated areas nowadays may represent a more radio-resistant population than reported in previous studies. Therefore, full-dose chemo-reirradiation should only be applied in well selected cases.
Keywords
Carcinoma, Squamous Cell/drug therapy, Carcinoma, Squamous Cell/mortality, Combined Modality Therapy/trends, Dose Fractionation, Head and Neck Neoplasms/drug therapy, Head and Neck Neoplasms/mortality, Humans, Neoplasm Recurrence, Local/drug therapy, Neoplasm Recurrence, Local/radiotherapy, Neoplasms, Second Primary/drug therapy, Neoplasms, Second Primary/radiotherapy, Salvage Therapy, Survival Rate, Treatment Outcome
Pubmed
Web of science
Create date
01/12/2014 17:30
Last modification date
20/08/2019 16:05
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