Modification of late epidermal differentiation in photoaged skin treated with topical retinoic acid cream

Détails

ID Serval
serval:BIB_E16A845B372E
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Modification of late epidermal differentiation in photoaged skin treated with topical retinoic acid cream
Périodique
Dermatology
Auteur(s)
Tur  E., Hohl  D., Jetten  A., Panizzon  R., Frenk  E.
ISSN
1018-8665 (Print)
Statut éditorial
Publié
Date de publication
1995
Volume
191
Numéro
2
Pages
124-8
Notes
Journal Article
Research Support, Non-U.S. Gov't
Résumé
BACKGROUND: Retinoic acid (RA) cream treatment alters epidermal proliferation and differentiation in photoaged skin. OBJECTIVE: To study the changes in the expression of markers of epidermal differentiation in photoaged skin following RA cream treatment. METHODS: Ten subjects with photoaged skin were examined before treatment and at regular intervals during 12 months of once daily application of 0.05% tretinoin cream over the left forearm. Paraffin-embedded biopsy sections from the forearm were stained with loricrin, filaggrin, involucrin and cornifin antisera in addition to hematoxylin and eosin. The various layers were measured using a calibrated optical micrometer. RESULTS: The thickness of the epidermis increased rapidly, reaching a substantial increase after 1 month of retinoid cream application and retaining it during the following 12 months. The stratum granulosum achieved a transient but substantial increase after 1 and 3 months. Except involucrin, the ratio between the layers expressing the various markers of epidermal differentiation and the epidermis significantly increased following tretinoin cream treatment. CONCLUSION: RA cream treatment not only increases the thickness of the epidermis but also the programming of late terminal epidermal differentiation, as expressed by the markers studied. Thus, RA appears to affect both proliferation and differentiation of keratinocytes in vivo.
Mots-clé
Administration, Topical Aged Aged, 80 and over Cell Differentiation/drug effects Epidermis/*drug effects/metabolism/pathology Humans Immunohistochemistry Intermediate Filament Proteins/metabolism Keratolytic Agents/administration & dosage/*pharmacology Membrane Proteins/metabolism Protein Precursors/metabolism Skin Aging/*drug effects/pathology Tretinoin/administration & dosage/*pharmacology
Pubmed
Web of science
Création de la notice
25/01/2008 16:54
Dernière modification de la notice
20/08/2019 16:05
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