Genomics of host-pathogen interactions.

Details

Serval ID
serval:BIB_E07AEE85CDEF
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Genomics of host-pathogen interactions.
Journal
Current Opinion in Immunology
Author(s)
Rausell A., Telenti A.
ISSN
1879-0372 (Electronic)
ISSN-L
0952-7915
Publication state
Published
Issued date
2014
Peer-reviewed
Oui
Volume
30C
Pages
32-38
Language
english
Notes
Publication types: REVIEW Publication Status: ppublishDocument Type: Review
Abstract
The study of immunity against infection can be framed in the context of genomics. First, long-term association with pathogens results in genomic signatures that result from positive selection. Evolutionary pressures tailor species or individual responses to pathogens, that may be associated with skewed patterns of immunity. Second, recent human population expansion carries an increasing burden of genetic mutation that can result in sporadic immunodeficiencies, and more generally, in diversity in susceptibility to infection. This review highlights current concepts and tools for the analysis of genomes and stresses the interest of these approaches in immunity.
Pubmed
Web of science
Create date
02/12/2014 17:43
Last modification date
20/08/2019 16:04
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