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Glucocorticoids increase beta-adrenoceptors on human intact lymphocytes in vitro.
A modification of beta-adrenoceptor binding has been observed in different human and animal tissues after glucocorticoid administration. In this study we observed that hydrocortisone increased human intact lymphocyte beta-adrenoceptors labelled with 3H-dyhydroalprenolol in vitro, in physiological and pharmacological concentrations. In saturation experiments hydrocortisone (10(-6)M) significantly raised beta-adrenoceptor Bmax and KD. Intact living lymphocytes seem to be a useful model for further investigation in man of the regulation of beta-adrenoceptors by glucocorticoids in physiological conditions.
Dihydroalprenolol/metabolism, Humans, Hydrocortisone/pharmacology, Kinetics, Lymphocytes/drug effects, Lymphocytes/metabolism, Receptors, Adrenergic, beta/drug effects, Receptors, Adrenergic, beta/metabolism
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