Glucocorticoids increase beta-adrenoceptors on human intact lymphocytes in vitro.

Détails

ID Serval
serval:BIB_E01BDB0635D9
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Glucocorticoids increase beta-adrenoceptors on human intact lymphocytes in vitro.
Périodique
Life Sciences
Auteur(s)
Cotecchia S., De Blasi A.
ISSN
0024-3205 (Print)
ISSN-L
0024-3205
Statut éditorial
Publié
Date de publication
1984
Volume
35
Numéro
23
Pages
2359-2364
Langue
anglais
Résumé
A modification of beta-adrenoceptor binding has been observed in different human and animal tissues after glucocorticoid administration. In this study we observed that hydrocortisone increased human intact lymphocyte beta-adrenoceptors labelled with 3H-dyhydroalprenolol in vitro, in physiological and pharmacological concentrations. In saturation experiments hydrocortisone (10(-6)M) significantly raised beta-adrenoceptor Bmax and KD. Intact living lymphocytes seem to be a useful model for further investigation in man of the regulation of beta-adrenoceptors by glucocorticoids in physiological conditions.
Mots-clé
Dihydroalprenolol/metabolism, Humans, Hydrocortisone/pharmacology, Kinetics, Lymphocytes/drug effects, Lymphocytes/metabolism, Receptors, Adrenergic, beta/drug effects, Receptors, Adrenergic, beta/metabolism
Pubmed
Web of science
Création de la notice
24/01/2008 11:05
Dernière modification de la notice
20/08/2019 16:04
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