Natural history, clinicopathologic classification and prognosis of gastric ECL cell tumors.

Détails

ID Serval
serval:BIB_DFA99B5920FD
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Natural history, clinicopathologic classification and prognosis of gastric ECL cell tumors.
Périodique
Yale Journal of Biology and Medicine
Auteur(s)
Solcia E., Rindi G., Paolotti D., Luinetti O., Klersy C., Zangrandi A., La Rosa S., Capella C.
ISSN
0044-0086 (Print)
ISSN-L
0044-0086
Statut éditorial
Publié
Date de publication
1998
Peer-reviewed
Oui
Volume
71
Numéro
3-4
Pages
285-290
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Résumé
A series of 50 gastric endocrine tumors classified according to Rindi et al. [1] comprised 12 small cell neuroendocrine carcinomas (NEC) and 38 ECL cell carcinoids, of which 22 associated with type A chronic atrophic gastritis (A-CAG), eight with hypertrophic gastropathy due to combined Multiple Endocrine Neoplasia and Zollinger/Ellison syndrome (MEN/ZES), and eight sporadic. Variables found to predict tumor malignancy were: size > 2 cm, > 2 mitoses and > 130 Ki67 positive cells/10 high power fields (HPF), grade 2 or 3 histology, angioinvasion, p53 protein nuclear accumulation, and the presence of a single tumor. None of these factors increased significantly the predicting ability of tumor classification itself, although grade 2 + 3 shows 100 percent negative predictive value and Ki67 and angioinvasion 100 percent positive predictive value. When the mostly non-malignant A-CAG and MEN-ZES tumors were analysed against the mostly malignant sporadic and NEC tumors, a positive predictive value of 90 percent and a negative predictive value of 93 percent was obtained. Investigation of a larger tumor series is under way with the aim to develop an optimal model for prognostic evaluation of gastric endocrine tumors.
Mots-clé
Adult, Aged, Carcinoma/pathology, Cell Differentiation, Cell Division, Enterochromaffin-like Cells/metabolism, Enterochromaffin-like Cells/pathology, Female, Gastrins/metabolism, Gastritis, Atrophic/pathology, Humans, Male, Middle Aged, Mitosis, Neuroendocrine Tumors/classification, Neuroendocrine Tumors/pathology, Predictive Value of Tests, Regression Analysis, Serotonin/metabolism, Somatostatin/metabolism, Stomach Neoplasms/classification, Stomach Neoplasms/pathology
Pubmed
Web of science
Création de la notice
07/09/2016 8:39
Dernière modification de la notice
20/08/2019 16:04
Données d'usage