Article: article from journal or magazin.
Inhibition and enhancement of in vitro helper activity of apocytochrome c-specific murine T cell populations and clones by anti-apocytochrome c-specific monoclonal antibodies.
European Journal of Immunology
A murine monoclonal antibody (mAb) specific for apocytochrome c was found to be able to either inhibit or enhance the helper activity of mouse apocytochrome c-specific T cell clones and populations in a hapten (trinitrophenyl)-carrier (apocytochrome c) system of T-B cell cooperation. This effect of the mAb was carrier specific, could not be ascribed simply to a shift in the kinetics of the antibody response and was observed using apocytochrome c T helper cells of different mouse haplotypes. In addition, the anti-apocytochrome c mAb was able to inhibit specific T helper cell activity even when the T cells were triggered with antigen-presenting cells pulsed with antigen. Taken together, these results suggested that the mAb was inhibiting helper activity due to its ability to modify the interaction between T cells and antigen-presenting cells.
Animals, Antibodies, Monoclonal/immunology, Antibody Formation, Antigen-Presenting Cells/immunology, Apoproteins/immunology, Clone Cells/immunology, Cytochrome c Group/immunology, Cytochromes c, Lymphocyte Activation, Lymphocyte Cooperation, Mice, Mice, Inbred BALB C/immunology, Mice, Inbred C57BL/immunology, Mice, Inbred DBA/immunology, T-Lymphocytes, Helper-Inducer/immunology
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