Sjogren-Lupus erythematodes-Uberlappungssyndrom. [Overlap of Sjogren-lupus erythematosus syndrome]

Détails

ID Serval
serval:BIB_DF64EB6413F2
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Titre
Sjogren-Lupus erythematodes-Uberlappungssyndrom. [Overlap of Sjogren-lupus erythematosus syndrome]
Périodique
Hautarzt
Auteur(s)
Trueb  R. M., Borelli  S., Schmid-Grendelmeier  P., Panizzon  R. G., Burg  G.
ISSN
0017-8470 (Print)
Statut éditorial
Publié
Date de publication
07/1995
Volume
46
Numéro
7
Pages
467-71
Notes
Case Reports
English Abstract
Journal Article --- Old month value: Jul
Résumé
Patients with anti-SSA(Ro)-positive Sjogren's syndrome (SS)/lupus erythematosus (LE) overlap are a immunogenetically, serologically and clinically homogeneous group; what they have in common is an increased frequency of the HLA-DR3 phenotype, demonstrating SSA(Ro) antibody activity and the typical annular, polycyclic, erythematous lesions of subacute cutaneous LE. The sicca symptoms of SS may develop long after the cutaneous lesions of LE have been present, or vice versa, as well as vasculitic, purpuric, and Sweet's syndrome-like lesions. The elderly, predominantly female patients are at enhanced risk for pulmonary and neurological disease, but glomerulonephritis occurs infrequently. We present an 81-year-old, SSA(Ro) antibody-positive and HLA-DR3-positive woman with SS/LE overlap syndrome, who had cutaneous LE for 30 years, developing sicca symptoms, vasculitic and Sweet's syndrome-like skin lesions only years after the LE symptoms. Although there is still some discussion as to whether phenotypical SS/LE overlap represents a distinct disease or is secondary SS in SLE or systemic SS with cutaneous involvement, the SS/LE overlap syndrome seems well enough delineated to be considered as a disease entity with separate implications for therapy and prognosis. Its position in the spectrum of anti-SSA(Ro) antibody- and HLA-DR3-positive diseases and its relationship to SS and to anti-SSA(Ro) antibody-positive LE are discussed.
Mots-clé
Aged Aged, 80 and over Antibodies, Antinuclear/blood Biopsy Diagnosis, Differential Female HLA-DR3 Antigen/genetics Humans Lupus Erythematosus, Cutaneous/*diagnosis/genetics/immunology Phenotype Salivary Glands, Minor/pathology Sjogren's Syndrome/*diagnosis/genetics/immunology Skin/pathology Sweet's Syndrome/diagnosis/genetics/immunology Vasculitis/diagnosis/genetics/immunology
Pubmed
Web of science
Création de la notice
25/01/2008 16:54
Dernière modification de la notice
20/08/2019 16:03
Données d'usage