Budd-Chiari syndrome complicating hepatic sarcoidosis: definitive treatment by liver transplantation: a case report.

Details

Serval ID
serval:BIB_DE0F80D02543
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Title
Budd-Chiari syndrome complicating hepatic sarcoidosis: definitive treatment by liver transplantation: a case report.
Journal
Transplantation Proceedings
Author(s)
Delfosse V., de Leval L., De Roover A., Delwaide J., Honoré P., Boniver J., Detry O.
ISSN
1873-2623[electronic], 0041-1345[linking]
Publication state
Published
Issued date
2009
Volume
41
Number
8
Pages
3432-3434
Language
english
Abstract
Sarcoidotic involvement of the liver is frequent, albeit uncommonly symptomatic. Severe complications are rare, but may seldom require liver transplantation. Budd-Chiari syndrome has been described in a few patients with hepatic sarcoidosis. Herein we have reported the case of a young woman suffering from hepatic sarcoidosis who developed severe cholestasis and chronic Budd-Chiari syndrome. She successfully underwent orthotopic liver transplantation (OLT) and is asymptomatic with normal liver function at 3 years follow-up. Histopathological assessment of the liver explant demonstrated a florid granulomatous process, with involvement of the large intrahepatic veins, providing an anatomical basis for the vascular flow disturbances. This case adds further evidence that liver transplantation may be the curative treatment for complicated sarcoidotic liver disease.
Keywords
Budd-Chiari Syndrome/complications, Budd-Chiari Syndrome/radiography, Female, Hepatic Veins/pathology, Hepatic Veins/radiography, Humans, Hyperbilirubinemia/complications, Liver Diseases/complications, Liver Diseases/pathology, Liver Transplantation, Lung/pathology, Lung/radiography, Middle Aged, Sarcoidosis/complications, Sarcoidosis/surgery, Tomography, X-Ray Computed, Treatment Outcome, Weight Loss
Pubmed
Create date
22/10/2010 10:35
Last modification date
20/08/2019 16:02
Usage data