Quorum-sensing systems in staphylococci as therapeutic targets.

Détails

ID Serval
serval:BIB_DDCE2CCCE289
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Quorum-sensing systems in staphylococci as therapeutic targets.
Périodique
Analytical and Bioanalytical Chemistry
Auteur(s)
Harraghy N., Kerdudou S., Herrmann M.
ISSN
1618-2642[print]
Statut éditorial
Publié
Date de publication
2007
Volume
387
Numéro
2
Pages
437-444
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Résumé
The staphylococci are an ever-present threat in our world, capable of causing a wide range of infections, and are a persistent presence in the clinical environment. As the number of antimicrobial compounds effective against staphylococci decreases, because of the acquisition and spread of antibiotic resistance, there is a growing need for novel therapeutic molecules. Intra and inter-species communication (quorum sensing) is a biologically significant phenomenon that has been associated with virulence, intracellular survival, and biofilm formation. Quorum sensing molecules of staphylococci and other species (e.g. Pseudomonas aeruginosa) can inhibit virulence factor production and/or growth of staphylococci, leading to the possibility that interference with staphylococcal quorum-sensing systems could be a way of controlling the diverse infections caused by the staphylococci. In this article, we discuss the potential of quorum-sensing systems of staphylococci as therapeutic targets.
Mots-clé
Anti-Bacterial Agents, Drug Delivery Systems, Quorum Sensing/drug effects, Staphylococcal Infections/drug therapy, Staphylococcus/drug effects, Staphylococcus/physiology
Pubmed
Web of science
Création de la notice
16/06/2010 11:26
Dernière modification de la notice
20/08/2019 16:02
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