Ossido nitrico (NO) e sviluppo renale normale e patologico [Nitric oxide (NO) and normal and pathologic renal development].

Details

Serval ID
serval:BIB_DD845C689156
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Ossido nitrico (NO) e sviluppo renale normale e patologico [Nitric oxide (NO) and normal and pathologic renal development].
Journal
La Pediatria Medica E Chirurgica : Medical and Surgical Pediatrics
Author(s)
Simeoni U., Helwig J.J.
ISSN
0391-5387 (Print)
ISSN-L
0391-5387
Publication state
Published
Issued date
1997
Peer-reviewed
Oui
Volume
19
Number
5
Pages
313-315
Language
italian
Notes
Publication types: English Abstract ; Journal Article ; Review Publication Status: ppublish
Abstract
Nitric oxide (NO) has been identified as the mediator accounting for the biological effects of endothelium-derived relaxing factor (EDRF) and has been shown to be generated by the action of constitutive and inducible NO-synthases (NOSs) from L-arginine in a variety of cells, including macrophages, neurons and endothelial cells. NO acts as an autocrine or paracrine mediator, its half-life being very short, within the range of few seconds. The NO produced in endothelial cells exerts potent, regional vasodilatatory effects. In the kidney, NO has been shown to play a key role in various processes in normal and pathological conditions. NO is involved in the control of renal basal vascular tone and the maintenance of low vascular resistance. Increasing data suggest that NO interacts with the renin angiotensin system to ultimately influence renal haemodynamic function.
Keywords
Animals, Humans, Kidney/blood supply, Kidney/physiology, Kidney Diseases/etiology, Kidney Glomerulus/physiology, Kidney Tubules/physiology, Nitric Oxide/antagonists & inhibitors, Nitric Oxide/physiology, Nitric Oxide Synthase/physiology, Renin-Angiotensin System/physiology, Vascular Resistance/physiology, Vasoconstriction/physiology
Pubmed
Create date
22/02/2015 11:15
Last modification date
20/08/2019 16:02
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