Assessing the possible direct effect of birth weight on childhood blood pressure : a sensitivity analysis.

Détails

Ressource 1Télécharger: BIB_DA30A9DB8769.P001.pdf (195.11 [Ko])
Etat: Serval
Version: Final published version
ID Serval
serval:BIB_DA30A9DB8769
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Assessing the possible direct effect of birth weight on childhood blood pressure : a sensitivity analysis.
Périodique
American Journal of Epidemiology
Auteur(s)
Chiolero A., Paradis G., Kaufman J.S.
ISSN
1476-6256 (Electronic)
ISSN-L
0002-9262
Statut éditorial
Publié
Date de publication
2014
Peer-reviewed
Oui
Volume
179
Numéro
1
Pages
4-11
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Résumé
To estimate the possible direct effect of birth weight on blood pressure, it is conventional to condition on the mediator, current weight. Such conditioning can induce bias. Our aim was to assess the potential biasing effect of U, an unmeasured common cause of current weight and blood pressure, on the estimate of the controlled direct effect of birth weight on blood pressure, with the help of sensitivity analyses. We used data from a school-based study conducted in Switzerland in 2005-2006 (n = 3,762; mean age = 12.3 years). A small negative association was observed between birth weight and systolic blood pressure (linear regression coefficient βbw = -0.3 mmHg/kg, 95% confidence interval: -0.9, 0.3). The association was strengthened upon adjustment for current weight (βbw|C = -1.5 mmHg/kg, 95% confidence interval: -2.1, -0.9). Sensitivity analyses revealed that the negative conditional association was explained by U only if U was relatively strongly associated with blood pressure and if there was a large difference in the prevalence of U between low-birth weight and normal-birth weight children. This weakens the hypothesis that the negative relationship between birth weight and blood pressure arises only from collider-stratification bias induced by conditioning on current weight.
Mots-clé
birth weight, blood pressure, collider-stratification bias, direct effects, sensitivity analyses
Pubmed
Web of science
Open Access
Oui
Création de la notice
07/02/2014 21:46
Dernière modification de la notice
09/05/2019 2:03
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