Pharmacokinetics of teicoplanin in children.

Détails

ID Serval
serval:BIB_D9FA8CF9FA2E
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Pharmacokinetics of teicoplanin in children.
Périodique
Journal of Antimicrobial Chemotherapy
Auteur(s)
Tarral E., Jehl F., Tarral A., Simeoni U., Monteil H., Willard D., Geisert J.
ISSN
0305-7453 (Print)
ISSN-L
0305-7453
Statut éditorial
Publié
Date de publication
1988
Peer-reviewed
Oui
Volume
21
Numéro
Suppl A
Pages
47-51
Langue
anglais
Notes
Publication types: Journal Article Publication Status: ppublish
Résumé
A single dose of 6 mg/kg teicoplanin was infused over 10 min in six children of mean age 7 years, and a single dose of 6 mg/kg was infused over 20 min in four neonates of mean age 8.5 days. Serum sampling was performed at 0 and 10 min and at 1, 4, 12 and 24 h and thereafter 24-hourly, up to ten days. Urine was collected for each 24 h throughout the study in children. Teicoplanin was assayed by high performance liquid chromatography. Tolerability of teicoplanin was excellent both in children and in neonates. For all the patients the serum concentrations of teicoplanin followed an open two-compartment model. Mean Cmax was 48.6 +/- 16.7 mg/l (10 min) in children, and 19.6 +/- 1.05 mg/l (20 min) in neonates, and mean t1/2 beta was 20.5 +/- 5.5 h and 30.3 +/- 6.3 h, respectively. On the basis of the results dosage recommendations for children and neonates are made.
Mots-clé
Adolescent, Anti-Bacterial Agents/administration & dosage, Anti-Bacterial Agents/pharmacokinetics, Child, Child, Preschool, Chromatography, High Pressure Liquid, Female, Glycopeptides/administration & dosage, Glycopeptides/pharmacokinetics, Humans, Infant, Newborn, Infusions, Intravenous, Injections, Intravenous, Male, Teicoplanin
Pubmed
Web of science
Création de la notice
22/02/2015 12:53
Dernière modification de la notice
03/03/2018 21:54
Données d'usage