Article: article from journal or magazin.
Two weeks of treatment with deprenyl (selegiline) does not prolong L-dopa effect in parkinsonian patients: a double-blind cross-over placebo-controlled trial.
Publication types: Clinical Trial ; Controlled Clinical Trial ; Journal ArticlePublication Status: ppublish
We investigated the influence of 2 weeks of treatment with deprenyl on the acute effect of a single dose of 200 mg of L-dopa in a double-blind cross-over placebo-controlled trial in 16 parkinsonian patients with wearing-off phenomena. Deprenyl induced no significant benefit in the duration or the maximal improvement of L-dopa's effect. Moreover, deprenyl treatment did not improve the patient's motor status.
Aged, Animals, Clinical Trials as Topic, Double-Blind Method, Drug Interactions, Female, Humans, Levodopa/administration & dosage, Levodopa/therapeutic use, Male, Middle Aged, Parkinson Disease/drug therapy, Phenethylamines/administration & dosage, Placebos, Selegiline/administration & dosage, Selegiline/therapeutic use
Web of science
Last modification date