Nouvelle cartographie fonctionnelle cérébrale: études sur la plasticité du cerveau humain.

Détails

ID Serval
serval:BIB_D9E11DEBD29A
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Nouvelle cartographie fonctionnelle cérébrale: études sur la plasticité du cerveau humain.
Périodique
Bulletin de l'Académie Nationale de Médecine
Auteur(s)
Frackowiak R.S.
ISSN
0001-4079 (Print)
ISSN-L
0001-4079
Statut éditorial
Publié
Date de publication
2001
Volume
185
Numéro
4
Pages
707-726
Langue
français
Notes
Human brain plasticity and mechanisms of functional recovery
Résumé
The non-invasive brain scanning techniques, introduced a quarter of a century ago, have become crucial for diagnosis in clinical neurology. They have also been used to investigate brain function and have provided information about normal activity and pathogenesis. They have been used to investigate functional specialisation in the brain and how specialised areas communicate to generate complex integrated functions such as speech, memory, the emotions and so on. Brain plasticity is a generic term that has now come to be used to signify any changes in brain structure or function. The phenomenon is poorly understood, and yet clinical neurologists are aware that spontaneous recovery from brain lesions is not uncommon. An improved understanding of the mechanisms of recovery may generate new therapeutic strategies and indicate ways of modulating mechanisms that promote plastic compensation for loss of function. The main methods used to investigate these issues are positron emission tomography and magnetic resonance imaging (MRI). The techniques of functional brain mapping and computational morphometrics depend on high performance scanners and a validated set of analytic statistical procedures that generate reproducible data and meaningful inferences from them. The motor system presents a good paradigm to illustrate advances made by scanning towards an understanding of plasticity at the level of brain areas. The normal motor system is organised in a nested hierarchy. Recovery from paralysis caused by internal capsule strokes involves functional reorganisation manifesting as changed patterns of activity in the component brain areas of the normal motor system. The pattern of plastic modification depends in part on patterns of residual or disturbed connectivity after brain injury. Therapeutic manipulations in patients with Parkinson's disease using deep brain stimulation, dopaminergic agents or foetal mesencephalic transplantation provide a means to examine mechanisms underpinning plastic change. Other models of plastic change, such as normal visuospatial learning or re-establishing speech comprehension after cochlear implantation in the deaf illustrate how patterns of brain function adapt over time. Limitations of the scanning techniques and prospects for the future are discussed in relation to new developments in the neuroimaging field.
Mots-clé
Brain/physiology, Brain Infarction/physiopathology, Brain Mapping/methods, Humans, Neuronal Plasticity
Pubmed
Web of science
Création de la notice
12/09/2011 20:10
Dernière modification de la notice
03/03/2018 21:53
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