Potential detrimental effects of a phytoestrogen-rich diet on male fertility in mice.

Détails

ID Serval
serval:BIB_D9C9CF4C4F35
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Potential detrimental effects of a phytoestrogen-rich diet on male fertility in mice.
Périodique
Molecular and cellular endocrinology
Auteur(s)
Cederroth C.R., Zimmermann C., Beny J.L., Schaad O., Combepine C., Descombes P., Doerge D.R., Pralong F.P., Vassalli J.D., Nef S.
ISSN
1872-8057 (Electronic)
ISSN-L
0303-7207
Statut éditorial
Publié
Date de publication
10/06/2010
Peer-reviewed
Oui
Volume
321
Numéro
2
Pages
152-160
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Soy and soy-based products are widely consumed by infants and adult individuals. There has been speculation that the presence of isoflavone phytoestrogens in soybean cause adverse effects on the development and function of the male reproductive system. The purpose of this study was to examine the influence of dietary soy and phytoestrogens on testicular and reproductive functions. Male mice were fed from conception to adulthood with either a high soy-containing diet or a soy-free diet. Although adult mice fed a soy-rich diet exhibited normal male behaviour and were fertile, we observed a reduced proportion of haploid germ cells in testes correlating with a 25% decrease in epididymal sperm counts and a 21% reduction in litter size. LH and androgens levels were not affected but transcripts coding for androgen-response genes in Sertoli cells and Gapd-s, a germ cell-specific gene involved in sperm glycolysis and mobility were significantly reduced. In addition, we found that dietary soy decreased the size of the seminal vesicle but without affecting its proteolytic activity. Taken together, these studies show that long-term exposure to dietary soy and phytoestrogens may affect male reproductive function resulting in a small decrease in sperm count and fertility.

Mots-clé
Animals, Blotting, Western, Diet, Fertility/physiology, Flow Cytometry, Hormones/blood, Isoflavones/blood, Male, Mice, Microarray Analysis, Phytoestrogens/metabolism, Reverse Transcriptase Polymerase Chain Reaction, Soybeans/metabolism, Sperm Count
Pubmed
Web of science
Création de la notice
08/06/2010 15:56
Dernière modification de la notice
03/03/2018 21:53
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