Recent advances in blood-related proteomics

Détails

ID Serval
serval:BIB_D9B440C4A865
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Recent advances in blood-related proteomics
Périodique
Proteomics
Auteur(s)
Thadikkaran  L., Siegenthaler  M. A., Crettaz  D., Queloz  P. A., Schneider  P., Tissot  J. D.
ISSN
1615-9853 (Print)
Statut éditorial
Publié
Date de publication
08/2005
Volume
5
Numéro
12
Pages
3019-34
Notes
Journal Article
Research Support, Non-U.S. Gov't
Review --- Old month value: Aug
Résumé
Blood is divided in two compartments, namely, plasma and cells. The latter contain red blood cells, leukocytes, and platelets. From a descriptive medical discipline, hematology has evolved towards a pioneering discipline where molecular biology has permitted the development of prognostic and diagnostic indicators for disease. The recent advance in MS and protein separation now allows similar progress in the analysis of proteins. Proteomics offers great promise for the study of proteins in plasma/serum, indeed a number of proteomics databases for plasma/serum have been established. This is a very complex body fluid containing lipids, carbohydrates, amino acids, vitamins, nucleic acids, hormones, and proteins. About 1500 different proteins have recently been identified, and a number of potential new markers of diseases have been characterized. Here, examples of the enormous promise of plasma/serum proteomic analysis for diagnostic/prognostic markers and information on disease mechanism are given. Within the blood are also a large number of different blood cell types that potentially hold similar information. Proteomics of red blood cells, until now, has not improved our knowledge of these cells, in contrast to the major progresses achieved while studying platelets and leukocytes. In the future, proteomics will change several aspects of hematology.
Mots-clé
Amyloid/chemistry Biological Markers Blood/*metabolism Blood Platelets/metabolism Cryoglobulins/chemistry Electrophoresis, Gel, Two-Dimensional Erythrocytes/cytology Hematology/methods Humans Leukemia/metabolism Leukocytes/cytology Protein Array Analysis Proteome Proteomics/*methods/trends
Pubmed
Web of science
Création de la notice
25/01/2008 16:34
Dernière modification de la notice
03/03/2018 21:53
Données d'usage