Lateral asymmetries in primary degenerative dementia of the Alzheimer type. A correlative study of cognitive, haemodynamic and EEG data, in relation with severity, age of onset and sex.

Details

Serval ID
serval:BIB_D9353A5385CF
Type
Article: article from journal or magazin.
Collection
Publications
Title
Lateral asymmetries in primary degenerative dementia of the Alzheimer type. A correlative study of cognitive, haemodynamic and EEG data, in relation with severity, age of onset and sex.
Journal
Cortex
Author(s)
Celsis P., Agniel A., Puel M., Le Tinnier A., Viallard G., Démonet J.F., Rascol A., Marc-Vergnes J.P.
ISSN
0010-9452 (Print)
ISSN-L
0010-9452
Publication state
Published
Issued date
1990
Peer-reviewed
Oui
Volume
26
Number
4
Pages
585-596
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish
Abstract
Cognitive, haemodynamic and EEG lateral asymmetries have been quantified in 20 patients with Primary Degenerative Dementia (PDD) and in 20 age-matched normal volunteers. Normalized asymmetry scores were calculated from the data obtained with a test battery, with SPECT and with quantitative EEG. Significant correlations were found between cognitive, haemodynamic and EEG scores in patients but not in controls. The functional asymmetries correlated to the Mini Mental State (MMS) score, the lowest MMS values being observed in patients with right hemisphere predominant impairment. Besides, in these patients, a significant correlation was observed between age at onset and MMS score so that, in this subgroup only, the earlier the onset the more severe the disease. Finally, the prevalence of pronounced functional asymmetry seemed to be higher in our male patients. Our study shows that lateral asymmetries are frequent in patients with PDD and that preferential lateralization of the abnormalities should be given further attention, especially with regards to age, sex and overall severity.
Keywords
Adult, Alzheimer Disease/diagnosis, Alzheimer Disease/physiopathology, Cerebral Cortex/physiopathology, Cerebrovascular Circulation/physiology, Cognition Disorders/diagnosis, Cognition Disorders/physiopathology, Dominance, Cerebral/physiology, Electroencephalography, Female, Humans, Male, Neuropsychological Tests, Tomography, Emission-Computed, Single-Photon
Pubmed
Web of science
Create date
24/03/2013 14:56
Last modification date
20/08/2019 15:58
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