Lateral asymmetries in primary degenerative dementia of the Alzheimer type. A correlative study of cognitive, haemodynamic and EEG data, in relation with severity, age of onset and sex.

Détails

ID Serval
serval:BIB_D9353A5385CF
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Lateral asymmetries in primary degenerative dementia of the Alzheimer type. A correlative study of cognitive, haemodynamic and EEG data, in relation with severity, age of onset and sex.
Périodique
Cortex
Auteur(s)
Celsis P., Agniel A., Puel M., Le Tinnier A., Viallard G., Démonet J.F., Rascol A., Marc-Vergnes J.P.
ISSN
0010-9452 (Print)
ISSN-L
0010-9452
Statut éditorial
Publié
Date de publication
1990
Peer-reviewed
Oui
Volume
26
Numéro
4
Pages
585-596
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: ppublish
Résumé
Cognitive, haemodynamic and EEG lateral asymmetries have been quantified in 20 patients with Primary Degenerative Dementia (PDD) and in 20 age-matched normal volunteers. Normalized asymmetry scores were calculated from the data obtained with a test battery, with SPECT and with quantitative EEG. Significant correlations were found between cognitive, haemodynamic and EEG scores in patients but not in controls. The functional asymmetries correlated to the Mini Mental State (MMS) score, the lowest MMS values being observed in patients with right hemisphere predominant impairment. Besides, in these patients, a significant correlation was observed between age at onset and MMS score so that, in this subgroup only, the earlier the onset the more severe the disease. Finally, the prevalence of pronounced functional asymmetry seemed to be higher in our male patients. Our study shows that lateral asymmetries are frequent in patients with PDD and that preferential lateralization of the abnormalities should be given further attention, especially with regards to age, sex and overall severity.
Mots-clé
Adult, Alzheimer Disease/diagnosis, Alzheimer Disease/physiopathology, Cerebral Cortex/physiopathology, Cerebrovascular Circulation/physiology, Cognition Disorders/diagnosis, Cognition Disorders/physiopathology, Dominance, Cerebral/physiology, Electroencephalography, Female, Humans, Male, Neuropsychological Tests, Tomography, Emission-Computed, Single-Photon
Pubmed
Web of science
Création de la notice
24/03/2013 15:56
Dernière modification de la notice
03/03/2018 21:52
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