Article: article from journal or magazin.
Localization of inhibin/activin subunits in normal pituitary and in pituitary adenomas.
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
The localization of inhibin/activin (I/A) subunits was investigated in human normal adenohypophysial cells and in 87 pituitary adenomas of different types, using immunohistochemistry. Monoclonal antibodies directed against alpha, beta A and beta B subunits of I/A were employed. In normal pituitary, alpha subunit of inhibin was detected only in FSH-positive gonadotrophs, while beta A subunit of I/A was expressed in FSH-positive gonadotrophs, GH-cells and in a few PRL-cells. beta B subunit was found in FSH-positive gonadotrophs, TSH-cells and a few LH-positive gonadotrophs. The three subunits of I/A were detected in the majority of nonfunctioning tumors, while functioning adenomas showed a significantly lower expression. This study shows that alpha, beta A and beta B subunits of I/A are expressed by specific adenohypophysial cell types and that they are characteristically present in nonfunctioning adenomas. These results suggest that inhibins and activins may play a role in the local regulation of pituitary hormonal secretion both in normal adenohypophysial cells and in pituitary adenomas.
Activins, Adenoma/metabolism, Adolescent, Adult, Aged, Aged, 80 and over, Child, Female, Humans, Immunohistochemistry, Inhibins/metabolism, Male, Middle Aged, Pituitary Gland/metabolism, Pituitary Neoplasms/metabolism, Protein Isoforms/metabolism, Tissue Distribution
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