Article: article from journal or magazin.
CEP-1347/KT7515, a JNK pathway inhibitor, supports the in vitro survival of chick embryonic neurons.
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Developing neurons depend on target-derived trophic factors for survival in vivo and in vitro, which also decrease the activity of c-Jun N-terminal kinase (JNK). We have recently described a survival-promoting effect of inhibitors of cyclin-dependent kinases and JNK on chick peripheral embryonic neurons. Here, we report that the small trophic molecule CEP-1347/KT7515, which has been shown to inhibit the JNK signalling pathway, can promote long term-survival of cultured chick embryonic dorsal root ganglion, sympathetic, ciliary and motor neurons. Because of their pharmacological properties, small trophic molecules such as CEP-1347/KT7515 might be of interest for the treatment of neurodegenerative disorders.
Animals, Calcium-Calmodulin-Dependent Protein Kinases/antagonists & inhibitors, Cell Survival/drug effects, Cells, Cultured, Chick Embryo, Enzyme Inhibitors/pharmacology, Ganglia, Parasympathetic/cytology, Ganglia, Spinal/cytology, Ganglia, Sympathetic/cytology, JNK Mitogen-Activated Protein Kinases, Mitogen-Activated Protein Kinases, Motor Neurons/cytology, Motor Neurons/drug effects, Neurons/cytology, Neurons/drug effects, Signal Transduction/drug effects
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