Article: article from journal or magazin.
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Les biomarqueurs prédictifs dans le cancer colorectal [Predictive biomarkers in colorectal cancer]
Revue médicale suisse
Publication types: English Abstract ; Journal Article - Publication Status: ppublish
While for many years the diagnosis and therapy of colon cancer did not change drastically, recently new drugs (irinotecan and oxaliplatin, used in adjuvant or neo-adjuvant approaches) and even more recently the introduction of therapies targeting the epidermal growth factor receptor (EGFR) through the monoclonal antibodies cetuximab and panitumumab, are revolutionizing the field. The finding that only patients with a tumor with a wild type (non mutated) KRAS gene respond to anti-EGFR therapy has also affected the way pathologists address colorectal cancer. Molecular analysis of the KRAS gene has become almost a routine in a very short period of time. Pathologists will have to be prepared for a new era: from standard morphology based diagnostic procedures to the prediction of response to therapy using molecular tools.
Antineoplastic Agents/therapeutic use, Colorectal Neoplasms/genetics, Colorectal Neoplasms/pathology, Genetic Markers, Humans, Proto-Oncogene Proteins/genetics, Receptor, Epidermal Growth Factor/antagonists & inhibitors, ras Proteins/genetics
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