Unresponsiveness of specific T cells to IL-12 is associated with active cutaneous leishmaniasis owing to Leishmania guyanensis.

Details

Serval ID
serval:BIB_D5114C5F379C
Type
Article: article from journal or magazin.
Collection
Publications
Title
Unresponsiveness of specific T cells to IL-12 is associated with active cutaneous leishmaniasis owing to Leishmania guyanensis.
Journal
Scandinavian Journal of Immunology
Author(s)
Bourreau E., Prévot G., Pradinaud R., Launois P.
ISSN
0300-9475 (Print)
ISSN-L
0300-9475
Publication state
Published
Issued date
2001
Volume
54
Number
3
Pages
335-339
Language
english
Abstract
The production of interleukin (IL)-13 and unresponsiveness to IL-12 in T cells were analyzed in patients with active localized cutaneous leishmaniasis (untreated or not responsive to treatment) and in patients who had been treated successfully for the disease. More IL-13 was produced by specific T cells in response to Leishmania guyanensis (L. guyanensis) antigens in active compared to in inactive leishmaniasis. Furthermore, unresponsiveness of specific T cells to IL-12 was detected only in patients with active leishmaniasis, i.e. in patients with detectable parasites such as untreated patients and patients unresponsive to treatment. These results support that IL-12 unresponsiveness of Leishmania-specific T cells is responsible for the persistence of infection.
Keywords
Animals, Antigens, Protozoan/immunology, Cells, Cultured, Humans, Interleukin-12/pharmacology, Interleukin-13/biosynthesis, Leishmania guyanensis/immunology, Leishmaniasis, Cutaneous/immunology, T-Lymphocytes, Helper-Inducer/immunology
Pubmed
Web of science
Open Access
Yes
Create date
28/01/2008 11:06
Last modification date
20/08/2019 15:54
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