Paraproteins and complement depletion: pathogenesis and clinical syndromes

Details

Serval ID
serval:BIB_D4419B49A3F0
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Paraproteins and complement depletion: pathogenesis and clinical syndromes
Journal
Seminars in Hematology
Author(s)
Pascual  M., Mach-Pascual  S., Schifferli  J. A.
ISSN
0037-1963
Publication state
Published
Issued date
01/1997
Peer-reviewed
Oui
Volume
34
Number
1 Suppl 1
Pages
40-8
Notes
Journal Article
Review --- Old month value: Jan
Abstract
Various clinical syndromes that associate paraproteinemia and complement depletion have been described in the last three decades. Among these, cryoglobulinemias, acquired Clq deficiency, and acquired deficiencies of the classical pathway of complement can be associated with B-cell lymphoproliferative disorders. Some specific symptoms should alert the clinician to suspect an underlying malignancy. In this report, we review the pathogenesis, symptomatology and therapeutic options of these clinical conditions.
Keywords
Agammaglobulinemia/physiopathology Complement C1q/deficiency Complement Pathway, Alternative/physiology Complement System Proteins/*metabolism Cryoglobulinemia/etiology Glomerulonephritis/etiology Humans Paraproteinemias/*etiology/metabolism Syndrome
Pubmed
Web of science
Create date
29/01/2008 13:52
Last modification date
20/08/2019 15:54
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