Article: article from journal or magazin.
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
The role of ubiquitin-proteasome system in glioma survival and growth.
Publication types: Journal Article ; Review Publication Status: ppublish. pdf type: review
High-grade gliomas represent a group of aggressive brain tumors with poor prognosis due to an inherent capacity of persistent cell growth and survival. The ubiquitin-proteasome system (UPS) is an intracellular machinery responsible for protein turnover. Emerging evidence implicates various proteins targeted for degradation by the UPS in key survival and proliferation signaling pathways of these tumors. In this review, we discuss the involvement of UPS in the regulation of several mediators and effectors of these pathways in malignant gliomas.
Animals, Brain Neoplasms/enzymology, Brain Neoplasms/metabolism, Cell Proliferation, Cell Survival, Glioma/enzymology, Glioma/metabolism, Humans, Intercellular Signaling Peptides and Proteins/metabolism, Proteasome Endopeptidase Complex/metabolism, Transcription Factors/metabolism, Ubiquitin/metabolism
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