The role of ubiquitin-proteasome system in glioma survival and growth.
Details
Serval ID
serval:BIB_D429F381C7CE
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
The role of ubiquitin-proteasome system in glioma survival and growth.
Journal
Growth Factors
ISSN
1029-2292 (Electronic)
ISSN-L
0897-7194
Publication state
Published
Issued date
2013
Volume
31
Number
3
Pages
106-113
Language
english
Notes
Publication types: Journal Article ; Review Publication Status: ppublish. pdf type: review
Abstract
High-grade gliomas represent a group of aggressive brain tumors with poor prognosis due to an inherent capacity of persistent cell growth and survival. The ubiquitin-proteasome system (UPS) is an intracellular machinery responsible for protein turnover. Emerging evidence implicates various proteins targeted for degradation by the UPS in key survival and proliferation signaling pathways of these tumors. In this review, we discuss the involvement of UPS in the regulation of several mediators and effectors of these pathways in malignant gliomas.
Keywords
Animals, Brain Neoplasms/enzymology, Brain Neoplasms/metabolism, Cell Proliferation, Cell Survival, Glioma/enzymology, Glioma/metabolism, Humans, Intercellular Signaling Peptides and Proteins/metabolism, Proteasome Endopeptidase Complex/metabolism, Transcription Factors/metabolism, Ubiquitin/metabolism
Pubmed
Web of science
Create date
11/07/2013 21:01
Last modification date
20/08/2019 16:54
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