Mixed pituitary adenoma/craniopharyngioma: clinical, morphological, immunohistochemical and ultrastructural study of a case, review of the literature, and pathogenetic and nosological considerations.

Détails

ID Serval
serval:BIB_D41DB765CB5F
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Titre
Mixed pituitary adenoma/craniopharyngioma: clinical, morphological, immunohistochemical and ultrastructural study of a case, review of the literature, and pathogenetic and nosological considerations.
Périodique
Pituitary
Auteur(s)
Finzi G., Cerati M., Marando A., Zoia C., Ferreli F., Tomei G., Castelnuovo P., La Rosa S., Capella C.
ISSN
1573-7403 (Electronic)
ISSN-L
1386-341X
Statut éditorial
Publié
Date de publication
2014
Peer-reviewed
Oui
Volume
17
Numéro
1
Pages
53-59
Langue
anglais
Notes
Publication types: Case Reports ; Journal Article ; ReviewPublication Status: ppublish
Résumé
Mixed pituitary adenoma/craniopharyngiomas are very rare tumors. Their pathogenesis is still unclear and it is not known whether they are collision tumors derived from independent stem cells or whether they originate from a single stem cell undergoing divergent differentiation. The latter hypothesis is supported by the close commixture between the two tumor components with transition areas that has been previously described. However, "hybrid" cells with both pituitary adenoma and craniopharyngioma features have never been described. In this paper we report a case of mixed pituitary adenoma/craniopharyngioma observed in a 75-year-old woman presenting with diplopia and slight increase of serum prolactin, who underwent endoscopic endonasal trans-sphenoidal tumor resection. Histologically, the tumor was composed of a typical pituitary silent subtype 2 ACTH cell adenoma admixed with islands of adamantinomatous craniopharyngioma. Electron microscopy showed that, in addition to distinct silent subtype 2 ACTH and craniopharyngioma cells, there were "hybrid" cells, showing characteristics of both pituitary adenoma and craniopharyngioma, consisting of small dense secretory granules, bundles of cytoplasmic filaments, and desmosomes. This ultrastructural finding was also confirmed by the presence of cells showing nuclear p40 expression and chromogranin A immunoreactivity. The close commixture between the two components and the ultrastructural and immunohistochemical findings demonstrate a common histogenesis of the two components and support the classification of the neoplasm as a mixed tumor. The patient completely recovered and, 10 months after surgery, head MR confirmed the complete resection of the lesion.
Mots-clé
Adenoma/pathology, Adenoma/ultrastructure, Adrenocorticotropic Hormone/analysis, Aged, Biomarkers, Tumor/analysis, Chromogranin A/analysis, Craniopharyngioma/pathology, Craniopharyngioma/ultrastructure, Female, Humans, Immunohistochemistry, Mixed Tumor, Malignant/pathology, Mixed Tumor, Malignant/ultrastructure, Pituitary Neoplasms/pathology, Pituitary Neoplasms/ultrastructure, Transcription Factors/analysis, Tumor Suppressor Proteins/analysis
Pubmed
Web of science
Création de la notice
06/09/2016 12:50
Dernière modification de la notice
20/08/2019 15:54
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