Modified cine inversion recovery pulse sequence for the quantification of myocardial T1 and gadolinium partition coefficient.

Details

Serval ID
serval:BIB_D107BD471746
Type
Article: article from journal or magazin.
Collection
Publications
Title
Modified cine inversion recovery pulse sequence for the quantification of myocardial T1 and gadolinium partition coefficient.
Journal
Journal of magnetic resonance imaging
Author(s)
Milanesi M., Barison A., Positano V., Masci P.G., De Marchi D., Marinelli L., Hardy C.J., Foo T.K., Landini L., Lombardi M.
ISSN
1522-2586 (Electronic)
ISSN-L
1053-1807
Publication state
Published
Issued date
01/2013
Peer-reviewed
Oui
Volume
37
Number
1
Pages
109-118
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
To optimize and validate a modified cine inversion recovery sequence (MCine-IR) for myocardial T1 quantification and gadolinium partition coefficient (λ(Gd)) estimation at 1.5 T.
The original version of the cine inversion recovery sequence was modified to allow fully transverse magnetization recovery between two successive inversion pulses. Sixty heart phases were acquired from a number of heart cycles determined on a patient heart rate basis. Phantom studies were carried out to find the optimal effective TR for myocardial and blood pool T1 quantifications in pre- and postcontrast studies. Four patients with myocardial infarct (MI) and 22 dilated cardiomyopathy (DCM) were investigated, as well as 11 healthy subjects used as controls.
Effective TR was identified to be 5000 msec and 2000 msec, respectively, for pre- and postcontrast studies. A longer precontrast (948 ± 102 msec) and shorter postcontrast (348 ± 27 msec) T1 in ischemic patients relative to DCM (815 ± 98 msec, P = 0.03 and 409 ± 42 msec, P = 0.001) were noted in delayed enhancement (DE) areas. In MI patients λ(Gd) resulted higher than in DCM in DE areas (609 ± 167 vs. 422 ± 52, P = 0.01) but lower in segments not exhibiting DE (355 ± 100 vs. 398 ± 54, P = 0.02).
It was feasible to measure T1 and λ(Gd) with MCine-IR and the results were in good agreement with the literature.

Keywords
Adult, Aged, Cardiomyopathy, Dilated/diagnosis, Cardiomyopathy, Dilated/pathology, Contrast Media/pharmacology, Diagnostic Imaging/methods, Female, Gadolinium/pharmacology, Heart/physiopathology, Heart Rate, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Cine/methods, Male, Middle Aged, Models, Statistical, Myocardial Infarction/diagnosis, Myocardial Infarction/pathology, Myocardium/pathology, Phantoms, Imaging
Pubmed
Web of science
Open Access
Yes
Create date
25/08/2017 20:46
Last modification date
20/08/2019 15:51
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