Sarcomas: genetics, signalling, and cellular origins. Part 2: TET-independent fusion proteins and receptor tyrosine kinase mutations1

Details

Serval ID
serval:BIB_CFC0664721CD
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Sarcomas: genetics, signalling, and cellular origins. Part 2: TET-independent fusion proteins and receptor tyrosine kinase mutations1
Journal
Journal of Pathology
Author(s)
Suva  M. L., Cironi  L., Riggi  N., Stamenkovic  I.
ISSN
0022-3417 (Print)
Publication state
Published
Issued date
2007
Volume
213
Number
2
Pages
117-130
Notes
PT - Journal Article PT - Research Support, Non-U.S. Gov't
Abstract
Although the mechanisms that underlie sarcoma development are still poorly understood, the identification of non-random chromosomal translocations and receptor tyrosine kinase mutations associated with defined sarcoma types has provided new insight into the pathogenesis of these tumours. In Part 1 of the review (J Pathol 2007;213:4-20), we addressed sarcomas that express fusion genes containing TET gene family products. Part 2 of the review summarizes our current understanding of the implications of fusion genes that do not contain TET family members in sarcoma development, as well as that of specific mutations in genes encoding receptor tyrosine kinases (RTKs). The final section will serve as a summary of both reviews and will attempt to provide a synthesis of some of the emerging principles of sarcomagenesis
Keywords
Research
Pubmed
Web of science
Create date
29/01/2008 18:35
Last modification date
20/08/2019 15:50
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