Agglutination and flocculation of stem cells collected by apheresis due to cryofibrinogen.

Details

Serval ID
serval:BIB_CCD6F498818D
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Agglutination and flocculation of stem cells collected by apheresis due to cryofibrinogen.
Journal
Bone marrow transplantation
Author(s)
Siegenthaler M.A., Vu D.H., Ebnöther M., Ketterer N., Luthi F., Schmid P., Bargetzi M., Gasparini D., Tissot J.D.
ISSN
0268-3369
Publication state
Published
Issued date
04/2004
Peer-reviewed
Oui
Volume
33
Number
7
Pages
765-7
Language
english
Notes
Publication types: Case Reports ; Journal Article - Publication Status: ppublish
Abstract
Collection of peripheral stem cells by apheresis is a well-described process. Here, investigations concerning 'agglutination and flocculation' of stem cells collected from two patients are described. In both cases, cryoproteins were observed and cryofibrinogen was identified using high-resolution two-dimensional electrophoresis. In one case, peripheral stem cells were collected after a second course of mobilization, and the cells were immediately washed at 37 degrees C before being frozen, allowing their use, despite the presence of cryofibrinogen. In the other case, 'agglutination' was reversed by warming the bag, and plasma was removed before freezing.
Keywords
Agglutination, Blood Component Removal, Cell Adhesion, Cryoglobulins, Cryopreservation, Electrophoresis, Gel, Two-Dimensional, Fibrinogens, Abnormal, Flocculation, Hematopoietic Stem Cell Transplantation, Hematopoietic Stem Cells, Humans, Male, Middle Aged, Transplantation, Autologous
Pubmed
Web of science
Open Access
Yes
Create date
25/01/2008 15:34
Last modification date
20/08/2019 15:47
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