Article: article from journal or magazin.
Case report (case report): feedback on an observation with a short commentary.
Agglutination and flocculation of stem cells collected by apheresis due to cryofibrinogen.
Bone marrow transplantation
Publication types: Case Reports ; Journal Article - Publication Status: ppublish
Collection of peripheral stem cells by apheresis is a well-described process. Here, investigations concerning 'agglutination and flocculation' of stem cells collected from two patients are described. In both cases, cryoproteins were observed and cryofibrinogen was identified using high-resolution two-dimensional electrophoresis. In one case, peripheral stem cells were collected after a second course of mobilization, and the cells were immediately washed at 37 degrees C before being frozen, allowing their use, despite the presence of cryofibrinogen. In the other case, 'agglutination' was reversed by warming the bag, and plasma was removed before freezing.
Agglutination, Blood Component Removal, Cell Adhesion, Cryoglobulins, Cryopreservation, Electrophoresis, Gel, Two-Dimensional, Fibrinogens, Abnormal, Flocculation, Hematopoietic Stem Cell Transplantation, Hematopoietic Stem Cells, Humans, Male, Middle Aged, Transplantation, Autologous
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