Decreased theta event-related synchronization during working memory activation is associated with progressive mild cognitive impairment

Details

Serval ID
serval:BIB_C9B7D0AFA43C
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Decreased theta event-related synchronization during working memory activation is associated with progressive mild cognitive impairment
Journal
Dementia and Geriatric Cognitive Disorders
Author(s)
Missonnier Pascal, Gold Gabriel, Herrmann François R., Fazio-Costa Lara, Michel Jean-Pierre, Deiber Marie-Pierre, Michon Agnès, Giannakopoulos Panteleimon
ISSN
1420-8008
Publication state
Published
Issued date
2006
Peer-reviewed
Oui
Volume
22
Number
3
Pages
250-259
Language
english
Notes
SAPHIRID:61594
Abstract
BACKGROUND: Among the different quantitative electroencephalographic markers, theta activity is known to reflect neural resources involved in memory processes and directed attention. Previous studies suggested that synchronization likelihood analysis in theta-band frequency might be a sensitive method to identify early alterations of neuronal networks in mild cognitive impairment (MCI). METHODS: We report here a longitudinal study of 24 MCI patients with theta event-related synchronization (ERS) analysis during the n-back working memory task and neuropsychological follow-up after 1 year. Statistical analysis included analysis of variance and logistic regression to assess the relationship between cognitive decline and theta ERS. RESULTS: Upon follow-up, 13 MCI patients showed progressive MCI and 11 remained stable. In both groups, the phasic increase in theta amplitude after stimulus presentation did not depend on working memory load and electrode sites. Progressive MCI cases displayed significantly lower theta ERS power over all electrode sites compared to stable MCI cases. Theta ERS was significantly related to the cognitive outcome explaining 15.5% of its variability. In terms of MCI classification, the best combination of sensitivity and specificity was 0.87 and 0.60, respectively, with an area under the corresponding receiver operating characteristic curve reaching 76%. CONCLUSIONS: The present data indicate that a decrease in the early phasic theta ERS power during working memory activation may predict cognitive decline in MCI. This phenomenon is not related to working memory load but may reflect the presence of early deficits in directed attention-related neural circuits in MCI. Copyright (c) 2006 S. Karger AG, Basel
Pubmed
Web of science
Create date
10/03/2008 11:04
Last modification date
20/08/2019 15:44
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