Article: article from journal or magazin.
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Indications and limitations of chemotherapy and targeted agents in non-small cell lung cancer brain metastases.
Cancer Treatment Reviews
Publication types: Journal Article ; Review Publication Status: ppublish Document Type: Review PDF : Cancer Treatment Reviews : Anti-Tumor Treatment
Lung cancer is characterized by the highest incidence of solid tumor-related brain metastases, which are reported with a growing incidence during the last decade. Prognostic assessment may help to identify subgroups of patients that could benefit from more aggressive therapy of metastatic disease, in particular when central nervous system is involved. The recent sub-classification of non-small cell lung cancer (NSCLC) into molecularly-defined "oncogene-addicted" tumors, the emergence of effective targeted treatments in molecularly defined patient subsets, global improvement of advanced NSCLC survival as well as the availability of refined new radiotherapy techniques are likely to impact on outcomes of patients with brain dissemination. The present review focuses on key evidence and research strategies for systemic treatment of patients with central nervous system involvement in non-small cell lung cancer.
Antineoplastic Combined Chemotherapy Protocols/pharmacokinetics, Antineoplastic Combined Chemotherapy Protocols/therapeutic use, Blood-Brain Barrier, Brain Neoplasms/drug therapy, Brain Neoplasms/secondary, Carcinoma, Non-Small-Cell Lung/drug therapy, Carcinoma, Non-Small-Cell Lung/secondary, Humans, Incidence, Lung Neoplasms/pathology, Molecular Targeted Therapy/methods, Prognosis, Quinazolines/administration & dosage, Radiosurgery, Receptor, Epidermal Growth Factor/drug effects, Receptor, Epidermal Growth Factor/genetics, Treatment Outcome
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