Tangential migration of neuronal precursors of glutamatergic neurons in the adult mammalian brain.

Détails

ID Serval
serval:BIB_C60E527C6509
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Tangential migration of neuronal precursors of glutamatergic neurons in the adult mammalian brain.
Périodique
Proceedings of the National Academy of Sciences of the United States of America
Auteur(s)
Sun G.J., Zhou Y., Stadel R.P., Moss J., Yong J.H., Ito S., Kawasaki N.K., Phan A.T., Oh J.H., Modak N., Reed R.R., Toni N., Song H., Ming G.L.
ISSN
1091-6490 (Electronic)
ISSN-L
0027-8424
Statut éditorial
Publié
Date de publication
2015
Peer-reviewed
Oui
Volume
112
Numéro
30
Pages
9484-9489
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Résumé
In a classic model of mammalian brain formation, precursors of principal glutamatergic neurons migrate radially along radial glia fibers whereas GABAergic interneuron precursors migrate tangentially. These migration modes have significant implications for brain function. Here we used clonal lineage tracing of active radial glia-like neural stem cells in the adult mouse dentate gyrus and made the surprising discovery that proliferating neuronal precursors of glutamatergic granule neurons exhibit significant tangential migration along blood vessels, followed by limited radial migration. Genetic birthdating and morphological and molecular analyses pinpointed the neuroblast stage as the main developmental window when tangential migration occurs. We also developed a partial "whole-mount" dentate gyrus preparation and observed a dense plexus of capillaries, with which only neuroblasts, among the entire population of progenitors, are directly associated. Together, these results provide insight into neuronal migration in the adult mammalian nervous system.
Mots-clé
Animals, Brain/metabolism, Brain Mapping/methods, Cell Movement, Dentate Gyrus/physiology, Female, Glutamine/chemistry, Green Fluorescent Proteins/metabolism, Hippocampus/physiology, Imaging, Three-Dimensional, Mice, Mice, Inbred C57BL, Mice, Transgenic, Microscopy, Confocal, Microscopy, Fluorescence, Models, Neurological, Neural Stem Cells/cytology, Neurogenesis/physiology, Neurons/cytology, Neurons/physiology
Pubmed
Web of science
Open Access
Oui
Création de la notice
24/12/2015 12:45
Dernière modification de la notice
09/05/2019 1:01
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