Suppression de la réponse pressive immédiate à la néphrectomie unilatérale par le peptide natriurétique auriculaire chez le rat [Suppression of the immediate pressive response to unilateral nephrectomy by atrial natriuretic peptide in the rat]

Détails

ID Serval
serval:BIB_C5F3A736CE87
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Suppression de la réponse pressive immédiate à la néphrectomie unilatérale par le peptide natriurétique auriculaire chez le rat [Suppression of the immediate pressive response to unilateral nephrectomy by atrial natriuretic peptide in the rat]
Périodique
Archives des Maladies du Coeur et des Vaisseaux
Auteur(s)
Valentin J.P., Ribstein J., Pussard E., Nussberger J., Neuser D., Mimran A.
ISSN
0003-9683
Statut éditorial
Publié
Date de publication
07/1990
Peer-reviewed
Oui
Volume
83
Numéro
8
Pages
1343-1346
Langue
français
Résumé
Unilateral nephrectomy (UNX) is associated with an immediate and transient increase in arterial pressure and in prompt natriuresis from the remaining kidney. The hypothesis that atrial natriuretic peptide (ANP) is involved in the acute adaptation to unilateral nephrectomy was tested in euvolemic anesthetized Sprague-Dawley rats. In a first series of experiments, an increase in circulating ir-ANP levels (from 23.5 +/- 3.6 to 66.3 +/- 12.8 fmol/ml; p less than 0.01) was found within 2 minutes following renal exclusion. In a second set of experiments, the ANP response was inhibited by performing a right atrial appendectomy, in order to eliminate the major source of ANP, or by intravenous administration of monoclonal antibodies directed against ANP. When UNX was performed in the control groups (sham atrial appendectomy and administration of non specific monoclonal antibodies), mean arterial pressure rose immediately (maximal about 12% within 4 minutes) and transiently (return to pre-UNX values within 20 minutes) after UNX. At the same time, central venous pressure, monitored in the right atrium, tended to decrease slightly. In rats pretreated by right atrial appendectomy or by monoclonal antibodies directed against ANP, arterial pressure increased to the same extent as observed in control groups; this increase however was significantly more prolonged. In control groups, urinary cGMP excretion, the biological marker of ANP, increased twofold in parallel with the natriuretic response. These two responses were blunted in right atrial appendectomized rats and in rats receiving antibodies against-ANP. These results suggest that atrial natriuretic peptide plays a major role in the immediate functional adaptation to unilateral nephrectomy by blunting the increase in blood pressure.(ABSTRACT TRUNCATED AT 250 WORDS)
Mots-clé
Animals, Antibodies, Monoclonal/diagnostic use, Atrial Natriuretic Factor/blood, Atrial Natriuretic Factor/physiology, Blood Pressure, Central Venous Pressure, Heart Atria, Hematocrit, Male, Natriuresis, Nephrectomy, Rats, Rats, Inbred Strains
Pubmed
Web of science
Création de la notice
05/03/2008 17:41
Dernière modification de la notice
03/03/2018 21:16
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