Rationale and first results of developing at-risk (prodromal) criteria for bipolar disorder.

Détails

ID Serval
serval:BIB_C570CB74950B
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Rationale and first results of developing at-risk (prodromal) criteria for bipolar disorder.
Périodique
Current Pharmaceutical Design
Auteur(s)
Bechdolf A., Ratheesh A., Wood S.J., Tecic T., Conus P., Nelson B., Cotton S.M., Chanen A.M., Amminger G.P., Ruhrmann S., Schultze-Lutter F., Klosterkötter J., Fusar Poli P., Yung A.R., Berk M., McGorry P.D.
ISSN
1873-4286 (Electronic)
ISSN-L
1381-6128
Statut éditorial
Publié
Date de publication
2012
Peer-reviewed
Oui
Volume
18
Numéro
4
Pages
358-375
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Bipolar affective disorder (BD) is a severe, recurrent and disabling disorder with devastating consequences for individuals, families and society. Although these hazards and costs provide a compelling rationale for development of early detection and early intervention strategies in BD, the development of at-risk criteria for first episode mania is still in an early stage of development. In this paper we review the literature with respect to the clinical, neuroantomical and neuropsychological data, which support this goal. We also describe our recently developed bipolar at-risk criteria (BAR). This criteria comprises the peak age range of the first onset of bipolar disorder, genetic risk, presenting with sub-threshold mania, cyclothymic features or depressive symptoms. An initial pilot evaluation of the BAR criteria in 22 subjects indicated conversion rates to proxies of first-episode mania of 23% within 265 days on average, and high specificity and sensitivity of the criteria. If prospective studies confirm the validity of the BAR criteria, then the criteria would have the potential to open up new avenues of research for indicated prevention in BD and might therefore offer opportunities to ameliorate the severity of, or even prevent BD.
Pubmed
Web of science
Création de la notice
15/03/2012 15:23
Dernière modification de la notice
20/08/2019 16:41
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