Evolutionary dynamics of immune-related genes and pathways in disease-vector mosquitoes.

Détails

ID Serval
serval:BIB_C5656B5FBE80
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Evolutionary dynamics of immune-related genes and pathways in disease-vector mosquitoes.
Périodique
Science
Auteur(s)
Waterhouse R.M., Kriventseva E.V., Meister S., Xi Z., Alvarez K.S., Bartholomay L.C., Barillas-Mury C., Bian G., Blandin S., Christensen B.M., Dong Y., Jiang H., Kanost M.R., Koutsos A.C., Levashina E.A., Li J., Ligoxygakis P., Maccallum R.M., Mayhew G.F., Mendes A., Michel K., Osta M.A., Paskewitz S., Shin S.W., Vlachou D., Wang L., Wei W., Zheng L., Zou Z., Severson D.W., Raikhel A.S., Kafatos F.C., Dimopoulos G., Zdobnov E.M., Christophides G.K.
ISSN
1095-9203 (Electronic)
ISSN-L
0036-8075
Statut éditorial
Publié
Date de publication
2007
Peer-reviewed
Oui
Volume
316
Numéro
5832
Pages
1738-1743
Langue
anglais
Résumé
Mosquitoes are vectors of parasitic and viral diseases of immense importance for public health. The acquisition of the genome sequence of the yellow fever and Dengue vector, Aedes aegypti (Aa), has enabled a comparative phylogenomic analysis of the insect immune repertoire: in Aa, the malaria vector Anopheles gambiae (Ag), and the fruit fly Drosophila melanogaster (Dm). Analysis of immune signaling pathways and response modules reveals both conservative and rapidly evolving features associated with different functional gene categories and particular aspects of immune reactions. These dynamics reflect in part continuous readjustment between accommodation and rejection of pathogens and suggest how innate immunity may have evolved.

Mots-clé
Aedes/genetics, Aedes/immunology, Animals, Anopheles/genetics, Anopheles/immunology, Antimicrobial Cationic Peptides/physiology, Carrier Proteins/genetics, Carrier Proteins/physiology, Drosophila melanogaster/genetics, Drosophila melanogaster/immunology, Evolution, Molecular, Genes, Insect, Immunity, Innate/genetics, Insect Proteins/genetics, Insect Proteins/physiology, Insect Vectors/genetics, Insect Vectors/immunology, Malaria/transmission, Melanins/metabolism, Multigene Family, Signal Transduction, Species Specificity
Pubmed
Web of science
Création de la notice
19/09/2017 12:01
Dernière modification de la notice
03/03/2018 21:15
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