Brain correlates of memory processes in patients with dementia of Alzheimer's type: a SPECT Activation Study.

Détails

ID Serval
serval:BIB_C4D5A2E0E36D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Brain correlates of memory processes in patients with dementia of Alzheimer's type: a SPECT Activation Study.
Périodique
Journal of Cerebral Blood Flow and Metabolism
Auteur(s)
Cardebat D., Démonet J.F., Puel M., Agniel A., Viallard G., Celsis P.
ISSN
0271-678X (Print)
ISSN-L
0271-678X
Statut éditorial
Publié
Date de publication
1998
Peer-reviewed
Oui
Volume
18
Numéro
4
Pages
457-462
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Résumé
Task-induced changes in regional cerebral blood flow (rCBF) during verbal episodic memory activation were compared in 17 right-handed patients with dementia of the Alzheimer's type (DAT) and 20 healthy volunteers. Regional cerebral blood flow was assessed using single photon emission computed tomography (SPECT) and an injection of 133Xe (xenon, isotope of mass 133) in 21 regions of interest (ROI) during rest, passive listening to 36 words, and memorizing of a 12-word list repeated three times. In healthy subjects, memory-listening comparison showed activation of a distributed system involving several left-sided ROI, especially the posterior inferior frontal region. In patients with DAT, the same pattern of activation was found for listening-rest comparison, and no significant changes were found in memory-listening comparison. During listening compared with rest, significant activation was observed in left-sided hypoperfused regions. A significant correlation between memory performance and rCBF recorded in patients with DAT during the memory task was found only in the right lateral frontal region, a region that was not hypoperfused significantly in patients. The involvement of this region might relate to either retrieval effort or actual performance of patients with DAT on the memory task.
Mots-clé
Aged, Alzheimer Disease/psychology, Alzheimer Disease/radionuclide imaging, Auditory Perception/physiology, Brain/physiopathology, Brain Mapping, Dominance, Cerebral, Female, Frontal Lobe/physiopathology, Humans, Male, Memory Disorders/physiopathology, Memory Disorders/radionuclide imaging, Memory, Short-Term/physiology, Middle Aged, Neuronal Plasticity, Tomography, Emission-Computed, Single-Photon, Xenon Radioisotopes/diagnostic use
Pubmed
Web of science
Création de la notice
24/03/2013 18:02
Dernière modification de la notice
20/08/2019 16:40
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