Article: article from journal or magazin.
Different antigen-presenting cells differ in their capacity to induce lymphokine production and proliferation of an apo-cytochrome c-specific T cell clone.
Journal of Immunology
The activation of an apo-cytochrome c-specific T cell clone was found to differ, depending on the antigen-presenting cell population. Whereas total syngeneic spleen cells and bone marrow macrophages could be shown to trigger proliferation, IL 2, and MAF production by the T cell clone, a B cell lymphoma only induced MAF secretion. Further studies demonstrated that this effect was not due to a different antigen processing by the B lymphoma or to limiting amounts of Ia and antigen molecules on the B lymphoma cell surface. The dissociation of induction of MAF production from IL-2 production/proliferation found with the different antigen-presenting cells indicates strongly that molecules other than Ia and antigen may be required for the complete functional activation of antigen-specific T cell clones.
Animals, Antigen-Presenting Cells/classification, Antigen-Presenting Cells/immunology, Apoproteins/immunology, B-Lymphocytes/immunology, Bone Marrow Cells, Cell Line, Clone Cells/classification, Clone Cells/immunology, Cytochrome c Group/immunology, Cytochromes c, Epitopes, Lymphocyte Activation, Lymphokines/biosynthesis, Lymphoma/immunology, Macrophages/immunology, Mice, Mice, Inbred BALB C, Spleen/cytology, T-Lymphocytes/classification, T-Lymphocytes/immunology
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