Article: article from journal or magazin.
Case report (case report): feedback on an observation with a short commentary.
Ipsilateral blepharospasm and contralateral hemidystonia and parkinsonism in a patient with a unilateral rostral brainstem-thalamic lesion: structural and functional abnormalities studied with CT, MRI, and PET scanning.
Publication types: Case Reports ; Journal ArticlePublication Status: ppublish
A patient developed progressive right hemidystonia in childhood. Subsequently, left-sided blepharospasm, slurred and stuttering speech, and right-sided rigidity and bradykinesia, responsive to dopamine agonists, appeared. Investigation with computed tomography and magnetic resonance imaging (MRI) at age 43 years revealed a left-sided calcified rostral brainstem-thalamic lesion of uncertain aetiology. Although no structural lesion was seen in the striatal regions, L-[18F]-fluorodopa uptake was severely diminished in the left striatum but normal on the right. Dopamine receptor binding identified by [11C]-methylspiperone was in the normal range on both sides.
Adult, Blepharospasm/pathology, Brain Stem/pathology, Corpus Striatum/metabolism, Dystonia/pathology, Eyelid Diseases/pathology, Humans, Magnetic Resonance Imaging, Male, Parkinson Disease/pathology, Receptors, Dopamine/metabolism, Receptors, Dopamine D2, Thalamus/pathology, Tomography, Emission-Computed, Tomography, X-Ray Computed
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